| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase ABL1 [229-512] |
|---|
| Ligand | BDBM13530 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Kinome-Wide Inhibitor Profiling for Phosphorylated c-Abl |
|---|
| Kd | 24±1 nM |
|---|
| Citation |  Kwarcinski, FE; Brandvold, KR; Phadke, S; Beleh, OM; Johnson, TK; Meagher, JL; Seeliger, MA; Stuckey, JA; Soellner, MB Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity. ACS Chem Biol11:1296-304 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase ABL1 [229-512] |
|---|
| Name: | Tyrosine-protein kinase ABL1 [229-512] |
|---|
| Synonyms: | ABL | ABL1 | ABL1_HUMAN | JTK7 | Tyrosine-protein kinase ABL1 (c-Abl) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 32850.19 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Human c-Abl kinase domain (229-512aa) |
|---|
| Residue: | 284 |
|---|
| Sequence: | SPNYDKWEMERTDITMKHKLGGGQYGEVYEGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA
VMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRECNRQEVNAVVLLYMATQIS
SAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAP
ESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKV
YELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGK
|
|
|
|---|
| BDBM13530 |
|---|
| n/a |
|---|
| Name | BDBM13530 |
|---|
| Synonyms: | 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide | CHEMBL941 | Gleevec | Imatinib | Imatinib, 21 | N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide | STI-571 | STI571 | US10906896, Cpd imatinib | US11649218, Example Imatinib | US11725005, Compound imatinib | US9255107, Imatinib | cid_5291 | imatinib-CD3 | med.21724, Compound 6 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C29H31N7O |
|---|
| Mol. Mass. | 493.6027 |
|---|
| SMILES | CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
