Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetVoltage-dependent calcium channel gamma-8 subunit
LigandBDBM288189
Substrate/Competitorn/a
Meas. Tech.Calcium Flux Assay
pH7.4±n/a
IC50 0.063±n/a nM
Commentsextracted
Citation Ameriks, MKGyuris, MLaforteza, BNLebold, TPMeyer, STRavula, SSavall, BMShireman, BTWade, WSGerencsér, J Fused bicylic pyridine compounds and their use as AMPA receptor modulators US Patent US10087185 Publication Date 10/2/2018
More Info.:Get all data from this article,  Assay Method
 
Voltage-dependent calcium channel gamma-8 subunit
Name:Voltage-dependent calcium channel gamma-8 subunit
Synonyms:CACNG6 | CACNG8 | CCG8_HUMAN | Neuronal voltage-gated calcium channel gamma-8 subunit | TARP gamma-8 | Transmembrane AMPAR regulatory protein gamma-8
Type:Enzyme Catalytic Domain
Mol. Mass.:43326.96
Organism:Homo sapiens (Human)
Description:Q8WXS5
Residue:425
Sequence:
MESLKRWNEERGLWCEKGVQVLLTTVGAFAAFGLMTIAISTDYWLYTRALICNTTNLTAG
GDDGTPHRGGGGASEKKDPGGLTHSGLWRICCLEGLKRGVCVKINHFPEDTDYDHDSAEY
LLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIILGAGILFVAAGLSNIIGVIVY
ISANAGEPGPKRDEEKKNHYSYGWSFYFGGLSFILAEVIGVLAVNIYIERSREAHCQSRS
DLLKAGGGAGGSGGSGPSAILRLPSYRFRYRRRSRSSSRSSEPSPSRDASPGGPGGPGFA
STDISMYTLSRDPSKGSVAAGLAGAGGGGGGAVGAFGGAAGGAGGGGGGGGGAGAERDRG
GASGFLTLHNAFPKEAGGGVTVTVTGPPAPPAPAPPAPSAPAPGTLAKEAAASNTNTLNR
KTTPV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM288189
n/a
NameBDBM288189
Synonyms:5-(7-Chloro-1H-indazol-5-yl)-2-(difluoromethyl)-6-(trifluoromethyl)- | US10087185, Example 7
TypeSmall organic molecule
Emp. Form.C15H7ClF5N5
Mol. Mass.387.695
SMILESFC(F)c1nc2ccc(c(-c3cc(Cl)c4[nH]ncc4c3)n2n1)C(F)(F)F
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: