| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Voltage-dependent calcium channel gamma-8 subunit |
|---|
| Ligand | BDBM288239 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Calcium Flux Assay |
|---|
| pH | 7.4±n/a |
|---|
| IC50 | 0.063±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Ameriks, MK; Gyuris, M; Laforteza, BN; Lebold, TP; Meyer, ST; Ravula, S; Savall, BM; Shireman, BT; Wade, WS; Gerencsér, J Fused bicylic pyridine compounds and their use as AMPA receptor modulators US Patent US10087185 Publication Date 10/2/2018 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Voltage-dependent calcium channel gamma-8 subunit |
|---|
| Name: | Voltage-dependent calcium channel gamma-8 subunit |
|---|
| Synonyms: | CACNG6 | CACNG8 | CCG8_HUMAN | Neuronal voltage-gated calcium channel gamma-8 subunit | TARP gamma-8 | Transmembrane AMPAR regulatory protein gamma-8 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 43326.96 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q8WXS5 |
|---|
| Residue: | 425 |
|---|
| Sequence: | MESLKRWNEERGLWCEKGVQVLLTTVGAFAAFGLMTIAISTDYWLYTRALICNTTNLTAG
GDDGTPHRGGGGASEKKDPGGLTHSGLWRICCLEGLKRGVCVKINHFPEDTDYDHDSAEY
LLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIILGAGILFVAAGLSNIIGVIVY
ISANAGEPGPKRDEEKKNHYSYGWSFYFGGLSFILAEVIGVLAVNIYIERSREAHCQSRS
DLLKAGGGAGGSGGSGPSAILRLPSYRFRYRRRSRSSSRSSEPSPSRDASPGGPGGPGFA
STDISMYTLSRDPSKGSVAAGLAGAGGGGGGAVGAFGGAAGGAGGGGGGGGGAGAERDRG
GASGFLTLHNAFPKEAGGGVTVTVTGPPAPPAPAPPAPSAPAPGTLAKEAAASNTNTLNR
KTTPV
|
|
|
|---|
| BDBM288239 |
|---|
| n/a |
|---|
| Name | BDBM288239 |
|---|
| Synonyms: | 5-(6-(4-Fluorophenyl)-2-(trifluoromethyl)-[1,2,4]triazolo[1,5- | US10087185, Example 57 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H14F4N4O |
|---|
| Mol. Mass. | 426.3664 |
|---|
| SMILES | Cc1cc(cc2CC(=O)Nc12)-c1c(ccc2nc(nn12)C(F)(F)F)-c1ccc(F)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
