| Reaction Details |
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 | Report a problem with these data |
| Target | Voltage-dependent calcium channel gamma-8 subunit |
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| Ligand | BDBM288249 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Calcium Flux Assay |
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| pH | 7.4±n/a |
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| IC50 | 0.050±n/a nM |
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| Comments | extracted |
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| Citation |  Ameriks, MK; Gyuris, M; Laforteza, BN; Lebold, TP; Meyer, ST; Ravula, S; Savall, BM; Shireman, BT; Wade, WS; Gerencsér, J Fused bicylic pyridine compounds and their use as AMPA receptor modulators US Patent US10087185 Publication Date 10/2/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Voltage-dependent calcium channel gamma-8 subunit |
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| Name: | Voltage-dependent calcium channel gamma-8 subunit |
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| Synonyms: | CACNG6 | CACNG8 | CCG8_HUMAN | Neuronal voltage-gated calcium channel gamma-8 subunit | TARP gamma-8 | Transmembrane AMPAR regulatory protein gamma-8 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 43326.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q8WXS5 |
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| Residue: | 425 |
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| Sequence: | MESLKRWNEERGLWCEKGVQVLLTTVGAFAAFGLMTIAISTDYWLYTRALICNTTNLTAG
GDDGTPHRGGGGASEKKDPGGLTHSGLWRICCLEGLKRGVCVKINHFPEDTDYDHDSAEY
LLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIILGAGILFVAAGLSNIIGVIVY
ISANAGEPGPKRDEEKKNHYSYGWSFYFGGLSFILAEVIGVLAVNIYIERSREAHCQSRS
DLLKAGGGAGGSGGSGPSAILRLPSYRFRYRRRSRSSSRSSEPSPSRDASPGGPGGPGFA
STDISMYTLSRDPSKGSVAAGLAGAGGGGGGAVGAFGGAAGGAGGGGGGGGGAGAERDRG
GASGFLTLHNAFPKEAGGGVTVTVTGPPAPPAPAPPAPSAPAPGTLAKEAAASNTNTLNR
KTTPV
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| BDBM288249 |
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| n/a |
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| Name | BDBM288249 |
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| Synonyms: | 5-(2-Cyclopropyl-6-(trifluoromethyl)pyrazolo[1,5-a]pyridin-7-yl)-7- | US10087185, Example 67 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H16F3N3O |
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| Mol. Mass. | 371.3557 |
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| SMILES | Cc1cc(cc2CC(=O)Nc12)-c1c(ccc2cc(nn12)C1CC1)C(F)(F)F |
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| Structure | 
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