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TargetVoltage-dependent calcium channel gamma-8 subunit
LigandBDBM288294
Substrate/Competitorn/a
Meas. Tech.Calcium Flux Assay
pH7.4±n/a
IC50 0.100±n/a nM
Commentsextracted
Citation Ameriks, MKGyuris, MLaforteza, BNLebold, TPMeyer, STRavula, SSavall, BMShireman, BTWade, WSGerencsér, J Fused bicylic pyridine compounds and their use as AMPA receptor modulators US Patent US10087185 Publication Date 10/2/2018
More Info.:Get all data from this article,  Assay Method
 
Voltage-dependent calcium channel gamma-8 subunit
Name:Voltage-dependent calcium channel gamma-8 subunit
Synonyms:CACNG6 | CACNG8 | CCG8_HUMAN | Neuronal voltage-gated calcium channel gamma-8 subunit | TARP gamma-8 | Transmembrane AMPAR regulatory protein gamma-8
Type:Enzyme Catalytic Domain
Mol. Mass.:43326.96
Organism:Homo sapiens (Human)
Description:Q8WXS5
Residue:425
Sequence:
MESLKRWNEERGLWCEKGVQVLLTTVGAFAAFGLMTIAISTDYWLYTRALICNTTNLTAG
GDDGTPHRGGGGASEKKDPGGLTHSGLWRICCLEGLKRGVCVKINHFPEDTDYDHDSAEY
LLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIILGAGILFVAAGLSNIIGVIVY
ISANAGEPGPKRDEEKKNHYSYGWSFYFGGLSFILAEVIGVLAVNIYIERSREAHCQSRS
DLLKAGGGAGGSGGSGPSAILRLPSYRFRYRRRSRSSSRSSEPSPSRDASPGGPGGPGFA
STDISMYTLSRDPSKGSVAAGLAGAGGGGGGAVGAFGGAAGGAGGGGGGGGGAGAERDRG
GASGFLTLHNAFPKEAGGGVTVTVTGPPAPPAPAPPAPSAPAPGTLAKEAAASNTNTLNR
KTTPV
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BDBM288294
n/a
NameBDBM288294
Synonyms:5-(7-Chloro-1H-indazol-5-yl)-2-cyclopropyl-6-(difluoromethyl)- | US10087185, Example 112
TypeSmall organic molecule
Emp. Form.C18H14ClF2N5
Mol. Mass.373.787
SMILESCc1cc(C(F)F)c(-c2cc(Cl)c3[nH]ncc3c2)n2nc(nc12)C1CC1
Structure
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