| Reaction Details |
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 | Report a problem with these data |
| Target | Voltage-dependent calcium channel gamma-8 subunit |
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| Ligand | BDBM288302 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Calcium Flux Assay |
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| pH | 7.4±n/a |
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| IC50 | 0.016±n/a nM |
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| Comments | extracted |
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| Citation |  Ameriks, MK; Gyuris, M; Laforteza, BN; Lebold, TP; Meyer, ST; Ravula, S; Savall, BM; Shireman, BT; Wade, WS; Gerencsér, J Fused bicylic pyridine compounds and their use as AMPA receptor modulators US Patent US10087185 Publication Date 10/2/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Voltage-dependent calcium channel gamma-8 subunit |
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| Name: | Voltage-dependent calcium channel gamma-8 subunit |
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| Synonyms: | CACNG6 | CACNG8 | CCG8_HUMAN | Neuronal voltage-gated calcium channel gamma-8 subunit | TARP gamma-8 | Transmembrane AMPAR regulatory protein gamma-8 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 43326.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q8WXS5 |
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| Residue: | 425 |
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| Sequence: | MESLKRWNEERGLWCEKGVQVLLTTVGAFAAFGLMTIAISTDYWLYTRALICNTTNLTAG
GDDGTPHRGGGGASEKKDPGGLTHSGLWRICCLEGLKRGVCVKINHFPEDTDYDHDSAEY
LLRVVRASSIFPILSAILLLLGGVCVAASRVYKSKRNIILGAGILFVAAGLSNIIGVIVY
ISANAGEPGPKRDEEKKNHYSYGWSFYFGGLSFILAEVIGVLAVNIYIERSREAHCQSRS
DLLKAGGGAGGSGGSGPSAILRLPSYRFRYRRRSRSSSRSSEPSPSRDASPGGPGGPGFA
STDISMYTLSRDPSKGSVAAGLAGAGGGGGGAVGAFGGAAGGAGGGGGGGGGAGAERDRG
GASGFLTLHNAFPKEAGGGVTVTVTGPPAPPAPAPPAPSAPAPGTLAKEAAASNTNTLNR
KTTPV
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| BDBM288302 |
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| n/a |
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| Name | BDBM288302 |
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| Synonyms: | 7-(7-Chloro-1H-indazol-5-yl)-6-(difluoromethyl)-2- | US10087185, Example 120 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H8ClF5N4 |
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| Mol. Mass. | 386.707 |
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| SMILES | FC(F)c1ccc2cc(nn2c1-c1cc(Cl)c2[nH]ncc2c1)C(F)(F)F |
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| Structure | 
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