| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-1 receptor-associated kinase 4 |
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| Ligand | BDBM187992 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 7.2±n/a |
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| IC50 | 1.5±n/a nM |
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| Citation |  Santella, JB; Kumar, SR; Duncia, JV; Gardner, DS; Paidi, VR; Nair, SK; Hynes, J; Wu, H; Murugesan, N; Sarkunam, K; Arunachalam, P Heteroaryl substituted nicotinamide compounds US Patent US9169252 Publication Date 10/27/2015 |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Interleukin-1 receptor-associated kinase 4 |
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| Name: | Interleukin-1 receptor-associated kinase 4 |
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| Synonyms: | IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64 |
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| Type: | Protein |
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| Mol. Mass.: | 51519.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NWZ3 |
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| Residue: | 460 |
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| Sequence: | MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALL
QTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITV
QQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNF
DERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKC
QHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGIN
FLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEAL
RGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMND
ADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
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| BDBM187992 |
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| n/a |
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| Name | BDBM187992 |
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| Synonyms: | US9169252, 532 | US9169252, 534 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26F2N10O2 |
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| Mol. Mass. | 548.5472 |
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| SMILES | CC(C)(O)[C@H](F)CNC(=O)c1cnc(cc1N[C@@H]1CCN(C1)c1ncc(F)cn1)-n1ncc2cc(cnc12)C#N |r| |
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| Structure | 
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