| Reaction Details |
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 | Report a problem with these data |
| Target | Pantothenate kinase |
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| Ligand | BDBM188496 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Biochemical Assay (ATP at Km) |
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| IC50 | 5.5e+2±n/a nM |
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| Citation |  Björkelid, C; Bergfors, T; Raichurkar, AK; Mukherjee, K; Malolanarasimhan, K; Bandodkar, B; Jones, TA Structural and biochemical characterization of compounds inhibiting Mycobacterium tuberculosis pantothenate kinase. J Biol Chem288:18260-70 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Pantothenate kinase |
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| Name: | Pantothenate kinase |
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| Synonyms: | COAA_MYCTU | Pantothenate kinase (PanK) | coaA |
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| Type: | Protein |
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| Mol. Mass.: | 35661.98 |
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| Organism: | Mycobacterium tuberculosis ATCC 25618/H37Rv |
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| Description: | n/a |
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| Residue: | 312 |
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| Sequence: | MSRLSEPSPYVEFDRRQWRALRMSTPLALTEEELVGLRGLGEQIDLLEVEEVYLPLARLI
HLQVAARQRLFAATAEFLGEPQQNPDRPVPFIIGVAGSVAVGKSTTARVLQALLARWDHH
PRVDLVTTDGFLYPNAELQRRNLMHRKGFPESYNRRALMRFVTSVKSGSDYACAPVYSHL
HYDIIPGAEQVVRHPDILILEGLNVLQTGPTLMVSDLFDFSLYVDARIEDIEQWYVSRFL
AMRTTAFADPESHFHHYAAFSDSQAVVAAREIWRTINRPNLVENILPTRPRATLVLRKDA
DHSINRLRLRKL
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| BDBM188496 |
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| n/a |
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| Name | BDBM188496 |
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| Synonyms: | Biaryl 2b |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25N5O2 |
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| Mol. Mass. | 427.4983 |
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| SMILES | NC(=O)COc1ccc(c(CN2CCN(CC2)c2ccccn2)c1)-c1ccc(cc1)C#N |
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| Structure | 
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