| Reaction Details |
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 | Report a problem with these data |
| Target | Glycogen synthase kinase-3 alpha |
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| Ligand | BDBM173196 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Mobility Shift Microfluidics Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 39± 30 nM |
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| Comments | extracted |
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| Citation |  Wagner, FF; Bishop, JA; Gale, JP; Shi, X; Walk, M; Ketterman, J; Patnaik, D; Barker, D; Walpita, D; Campbell, AJ; Nguyen, S; Lewis, M; Ross, L; Weïwer, M; An, WF; Germain, AR; Nag, PP; Metkar, S; Kaya, T; Dandapani, S; Olson, DE; Barbe, AL; Lazzaro, F; Sacher, JR; Cheah, JH; Fei, D; Perez, J; Munoz, B; Palmer, M; Stegmaier, K; Schreiber, SL; Scolnick, E; Zhang, YL; Haggarty, SJ; Holson, EB; Pan, JQ Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects. ACS Chem Biol11:1952-63 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glycogen synthase kinase-3 alpha |
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| Name: | Glycogen synthase kinase-3 alpha |
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| Synonyms: | GSK-3 alpha | GSK3A | GSK3A_HUMAN | Glycogen synthase kinase 3 alpha (GSKalpha) | Glycogen synthase kinase-3 | Glycogen synthase kinase-3 alpha | Glycogen synthase kinase-3 alpha (GSK3 Alpha) | Glycogen synthase kinase-3 alpha (GSK3A) | Glycogen synthase kinase-3 alpha (GSK3alpha) |
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| Type: | Enzyme |
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| Mol. Mass.: | 50991.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P49840 |
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| Residue: | 483 |
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| Sequence: | MSGGGPSGGGPGGSGRARTSSFAEPGGGGGGGGGGPGGSASGPGGTGGGKASVGAMGGGV
GASSSGGGPGGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYT
DIKVIGNGSFGVVYQARLAETRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFY
SSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPILYVKVYMYQLFRSLAYIHSQGV
CHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSS
IDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIK
AHPWTKVFKSRTPPEAIALCSSLLEYTPSSRLSPLEACAHSFFDELRCLGTQLPNNRPLP
PLFNFSAGELSIQPSLNAILIPPHLRSPAGTTTLTPSSQALTETPTSSDWQSTDATPTLT
NSS
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| BDBM173196 |
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| n/a |
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| Name | BDBM173196 |
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| Synonyms: | 4-(2-methoxyphenyl)-3,7,7-trimethyl-2,4,6,7,8,9-hexahydro-5H-pyrazolo[3,4-b]quinolin-5-one (12) | US10137122, Compound 20 | US9096594, 22 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H23N3O2 |
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| Mol. Mass. | 337.4155 |
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| SMILES | COc1ccccc1C1c2c(C)[nH]nc2NC2=C1C(=O)CC(C)(C)C2 |c:18| |
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| Structure | 
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