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TargetGlycogen synthase kinase-3 beta
LigandBDBM188508
Substrate/Competitorn/a
Meas. Tech.Mobility Shift Microfluidics Assay
pH7.5±n/a
Temperature298.15±n/a K
IC50 102± 81 nM
Commentsextracted
Citation Wagner, FFBishop, JAGale, JPShi, XWalk, MKetterman, JPatnaik, DBarker, DWalpita, DCampbell, AJNguyen, SLewis, MRoss, LWeïwer, MAn, WFGermain, ARNag, PPMetkar, SKaya, TDandapani, SOlson, DEBarbe, ALLazzaro, FSacher, JRCheah, JHFei, DPerez, JMunoz, BPalmer, MStegmaier, KSchreiber, SLScolnick, EZhang, YLHaggarty, SJHolson, EBPan, JQ Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects. ACS Chem Biol11:1952-63 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Glycogen synthase kinase-3 beta
Name:Glycogen synthase kinase-3 beta
Synonyms:GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:Enzyme
Mol. Mass.:46756.38
Organism:Homo sapiens (Human)
Description:P49841
Residue:420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTK
VIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSG
EKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHR
DIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDV
WSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHP
WTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALF
NFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
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  Blast E-value cutoff:
BDBM188508
n/a
NameBDBM188508
Synonyms:3,7,7-Trimethyl-4-(o-tolyl)-2,4,6,7,8,9-hexahydro-5H-pyrazolo[3,4-b]quinolin-5-one (11) | US10137122, Compound 17
TypeSmall organic molecule
Emp. Form.C20H23N3O
Mol. Mass.321.4161
SMILESCc1[nH]nc2NC3=C(C(c12)c1ccccc1C)C(=O)CC(C)(C)C3 |c:6|
Structure
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