Reaction Details |
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Target | Histone deacetylase 3 |
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Ligand | BDBM49152 |
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Substrate/Competitor | n/a |
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Meas. Tech. | HDAC Enzymatic Assay |
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pH | 7.4±n/a |
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IC50 | 6.51e+4±n/a nM |
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Comments | extracted |
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Citation | Boskovic, ZV; Kemp, MM; Freedy, AM; Viswanathan, VS; Pop, MS; Fuller, JH; Martinez, NM; Figueroa Lazú, SO; Hong, JA; Lewis, TA; Calarese, D; Love, JD; Vetere, A; Almo, SC; Schreiber, SL; Koehler, AN Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile. ACS Chem Biol11:1844-51 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 3 |
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Name: | Histone deacetylase 3 |
Synonyms: | HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45 |
Type: | Enzyme |
Mol. Mass.: | 48829.55 |
Organism: | Homo sapiens (Human) |
Description: | O15379 |
Residue: | 428 |
Sequence: | MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
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BDBM49152 |
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n/a |
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Name | BDBM49152 |
Synonyms: | 5-chloranyl-7-[(4-ethylpiperazin-1-yl)-pyridin-3-yl-methyl]quinolin-8-ol | 5-chloro-7-[(4-ethyl-1-piperazinyl)-(3-pyridinyl)methyl]-8-quinolinol | 5-chloro-7-[(4-ethylpiperazin-1-yl)-pyridin-3-ylmethyl]quinolin-8-ol | 5-chloro-7-[(4-ethylpiperazino)-(3-pyridyl)methyl]quinolin-8-ol | BRD4354 | MLS000564806 | SMR000151966 | cid_3516032 |
Type | Small organic molecule |
Emp. Form. | C21H23ClN4O |
Mol. Mass. | 382.887 |
SMILES | CCN1CCN(CC1)C(c1cccnc1)c1cc(Cl)c2cccnc2c1O |
Structure |
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