| Reaction Details |
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 | Report a problem with these data |
| Target | Tyrosyl-DNA phosphodiesterase 2 [E242G,S244A,Q278R,I281T,K282R,R316G,P318T,Y321CH323L] |
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| Ligand | BDBM50438865 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Recombinant TDP2 Assay |
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| pH | 7.5±n/a |
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| IC50 | 260±n/a nM |
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| Comments | extracted |
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| Citation |  Marchand, C; Abdelmalak, M; Kankanala, J; Huang, SY; Kiselev, E; Fesen, K; Kurahashi, K; Sasanuma, H; Takeda, S; Aihara, H; Wang, Z; Pommier, Y Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2. ACS Chem Biol11:1925-33 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Tyrosyl-DNA phosphodiesterase 2 [E242G,S244A,Q278R,I281T,K282R,R316G,P318T,Y321CH323L] |
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| Name: | Tyrosyl-DNA phosphodiesterase 2 [E242G,S244A,Q278R,I281T,K282R,R316G,P318T,Y321CH323L] |
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| Synonyms: | TYDP2_MOUSE | Tdp2 | Ttrap | Tyrosyl-DNA phosphodiesterase 2 mutant 9M(mTDP2 9M) |
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| Type: | Protein |
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| Mol. Mass.: | 40804.32 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | The mTDP2 9M bears the mutations at residues Q278R, I281T, K282R, P318T, Y321C, E242G, S244A, R316G, and H323L. |
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| Residue: | 370 |
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| Sequence: | MASGSSSDAAEPAGPAGRAASAPEAAQAEEDRVKRRRLQCLGFALVGGCDPTMVPSVLRE
NDWQTQKALSAYFELPENDQGWPRQPPTSFKSEAYVDLTNEDANDTTILEASPSGTPLED
SSTISFITWNIDGLDGCNLPERARGVCSCLALYSPDVVFLQEVIPPYCAYLKKRAASYTI
ITGNEEGYFTAILLKKGRVKFKSQEIIPFPNTKMMRNLLCVNVSLGGNEFCLMTSHLEST
RGHAAERIRQLKTVLGKMQEAPDSTTVIFAGDTNLRDREVTRCGGLPDNVFDAWEFLGKP
KHCQYTWDTKANNNLGITAACKLRFDRIFFRAEEGHLIPQSLDLVGLEKLDCGRFPSDHW
GLLCTLNVVL
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| BDBM50438865 |
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| n/a |
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| Name | BDBM50438865 |
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| Synonyms: | 2,4-Dioxo-10-phenyl-pyrimido[4,5-b]quinoline-8-carbonitrile (3) | CHEMBL2420506 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H10N4O2 |
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| Mol. Mass. | 314.2976 |
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| SMILES | O=c1nc2n(-c3ccccc3)c3cc(ccc3cc2c(=O)[nH]1)C#N |
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| Structure | 
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