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TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B
LigandBDBM5544
Substrate/CompetitorHistone H1
Meas. Tech.Kinase Inhibition Assay
IC50 9.5±n/a nM
Citation Hardcastle, IRArris, CEBentley, JBoyle, FTChen, YCurtin, NJEndicott, JAGibson, AEGolding, BTGriffin, RJJewsbury, PMenyerol, JMesguiche, VNewell, DRNoble, MEPratt, DJWang, LZWhitfield, HJ N2-substituted O6-cyclohexylmethylguanine derivatives: potent inhibitors of cyclin-dependent kinases 1 and 2. J Med Chem47:3710-22 (2004) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B
Name:Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B
Synonyms:CDK1/Cyclin B | Cyclin-Dependent Kinase 1 (CDK1) | p34cdc2/Cyclin B
Type:Protein Complex
Mol. Mass.:n/a
Description:p34cdc2/cyclin B was purified from M-phase starfish oocytes by affinity chromatography.
Components:This complex has 2 components.
Component 1
Name:Cyclin-dependent kinase 1
Synonyms:CDK1_ORYLA | Cell division control protein 2 (cdc2) | P34 protein kinase | cdc2 | cdk1
Type:Enzyme Subunit
Mol. Mass.:34693.35
Organism:Marthasterias glacialis (starfish)
Description:Q9DGD3 {empty hard to find)
Residue:303
Sequence:
MEDYVKIEKIGEGTYGVVYKGRHKSTGQVVAMKKIRLESEEEGVPSTAVREVSLLQELKH
PNVVRLLDVLMQESRLYLIFEFLSMDLKKYLDSIPSGQYMDPMLVKSYLYQILEGIYFCH
RRRVLHRDLKPQNLLIDNKGVIKLADFGLARAFGVPVRVYTHEVVTLWYRAPEVLLGSPR
YSTPVDVWSTGTIFAELATKKPLFHGDSEIDQLFRIFRTLGTPNNDVWPDVESLPDYKNT
FPKWKEGSLSSMVKNLDKNGLDLLAKMLIYNPPKRISAREAMTHPYFDDLDKSTLPAACI
NGV
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Component 2
Name:G2/mitotic-specific cyclin-B
Synonyms:CCNB_MARGL | Cyclin B | G2/mitotic-specific cyclin-B1
Type:Enzyme Subunit
Mol. Mass.:43790.28
Organism:Marthasterias glacialis (starfish)
Description:n/a
Residue:388
Sequence:
MLNGENVDSRIMGKVATRASSKGVKSTLGTRGALENISNVARNNLQAGAKKELVKAKRGM
TKSKATSSLQSVMGLNVEPMEKAKPQSPEPMDMSEINSALEAFSQNLLEGVEDIDKNDFD
NPQLCSEFVNDIYQYMRKLEREFKVRTDYMTIQEITERMRSILIDWLVQVHLRFHLLQET
LFLTIQILDRYLEVQPVSKNKLQLVGVTSMLIAAKYEEMYPPEIGDFVYITDNAYTKAQI
RSMECNILRRLDFSLGKPLCIHFLRRNSKAGGVDGQKHTMAKYLMELTLPEYAFVPYDPS
EIAAAALCLSSKILEPDMEWGTTLVHYSAYSEDHLMPIVQKMALVLKNAPTAKFQAVRKK
YSSAKFMNVSTISALTSSTVMDLADQMC
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BDBM5544
Histone H1
Name:Histone H1
Synonyms:Sigma Type IIIS
Type:Other Protein Type
Mol. Mass.:358.43
Organism:Bos taurus (bovine)
Description:12.5 uM ATP as co-substrate.
Residue:3
Sequence:
n/a