| Reaction Details |
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 | Report a problem with these data |
| Target | Kinesin-like protein KIF11 [15-368] |
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| Ligand | BDBM189361 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ADP Hunter Plus Assay |
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| pH | 7±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 1.183e+5±n/a nM |
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| Comments | extracted |
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| Citation |  Zhang, W; Zhai, L; Lu, W; Boohaker, RJ; Padmalayam, I; Li, Y Discovery of Novel Allosteric Eg5 Inhibitors Through Structure-Based Virtual Screening. Chem Biol Drug Des88:178-87 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Kinesin-like protein KIF11 [15-368] |
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| Name: | Kinesin-like protein KIF11 [15-368] |
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| Synonyms: | EG5 | KIF11 | KIF11_HUMAN | KNSL1 | Mitotic kinesin Eg5 (Eg5) | TRIP5 |
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| Type: | Protein |
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| Mol. Mass.: | 39484.97 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Eg5 motor domain (15-368aa) |
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| Residue: | 354 |
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| Sequence: | KGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGLADKSSRKTYTFDMVFGA
STKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTGTGKTFTMEGERSPNEEYTWEEDPLAG
IIPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMFDDPRNKRGV
IIKGLEEITVHNKDEVYQILEKGAAKRTTAATLMNAYSSRSHSVFSVTIHMKETTIDGEE
LVKIGKLNLVDLAGSENIGRSGAVDKRAREAGNINQSLLTLGRVITALVERTPHVPYRES
KLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNILNKPEVNQK
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| BDBM189361 |
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| n/a |
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| Name | BDBM189361 |
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| Synonyms: | SRI35564 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H12N6 |
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| Mol. Mass. | 252.2746 |
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| SMILES | Cc1ccc(cc1)C1C(C#N)=C(N)Nc2ncnn12 |t:11| |
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| Structure | 
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