Reaction Details |
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Target | Acetylcholinesterase |
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Ligand | BDBM189376 |
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Substrate/Competitor | n/a |
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Meas. Tech. | AChE Inhibitory Assay |
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pH | 7.7±n/a |
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IC50 | 88±7.5 nM |
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Comments | extracted |
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Citation | Shaik, JB; Palaka, BK; Penumala, M; Eadlapalli, S; Darla Mark, M; Ampasala, DR; Vadde, R; Amooru Gangaiah, D Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease. Chem Biol Drug Des88:43-53 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Acetylcholinesterase |
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Name: | Acetylcholinesterase |
Synonyms: | ACES_ELEEL | Acetylcholinesterase (AChE) | Acetylcholinesterase (EeAChE) | ache |
Type: | Enzyme |
Mol. Mass.: | 71812.79 |
Organism: | Electrophorus electricus (Electric eel) |
Description: | n/a |
Residue: | 633 |
Sequence: | MKILDALLFPVIFIMFFIHLSIAQTDPELTIMTRLGQVQGTRLPVPDRSHVIAFLGIPFA
EPPLGKMRFKPPEPKKPWNDVFDARDYPSACYQYVDTSYPGFSGTEMWNPNRMMSEDCLY
LNVWVPATPRPHNLTVMVWIYGGGFYSGSSSLDVYDGRYLAHSEKVVVVSMNYRVSAFGF
LALNGSAEAPGNVGLLDQRLALQWVQDNIHFFGGNPKQVTIFGESAGAASVGMHLLSPDS
RPKFTRAILQSGVPNGPWRTVSFDEARRRAIKLGRLVGCPDGNDTDLIDCLRSKQPQDLI
DQEWLVLPFSGLFRFSFVPVIDGVVFPDTPEAMLNSGNFKDTQILLGVNQNEGSYFLIYG
APGFSKDNESLITREDFLQGVKMSVPHANEIGLEAVILQYTDWMDEDNPIKNREAMDDIV
GDHNVVCPLQHFAKMYAQYSILQGQTGTASQGNLGWGNSGSASNSGNSQVSVYLYMFDHR
ASNLVWPEWMGVIHGYEIEFVFGLPLEKRLNYTLEEEKLSRRMMKYWANFARTGNPNINV
DGSIDSRRRWPVFTSTEQKHVGLNTDSLKVHKGLKSQFCALWNRFLPRLLNVTENIDDAE
RQWKAEFHRWSSYMMHWKNQFDHYSKQERCTNL
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BDBM189376 |
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n/a |
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Name | BDBM189376 |
Synonyms: | N-(3-chlorobenzyl)-8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene-9-carboxamide (4o) |
Type | Small organic molecule |
Emp. Form. | C20H13ClN2O4 |
Mol. Mass. | 380.781 |
SMILES | Clc1cccc(CNC(=O)c2cc3c(ccc4ccc(=O)oc34)oc2=N)c1 |
Structure |
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