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TargetCoagulation factor VII
LigandBDBM189448
Substrate/Competitorn/a
Meas. Tech.In Vitro Assay
Ki 0.14±n/a nM
Citation Zhang XGlunz PPriestley ESJohnson JAWurtz NRLadziata V Macrocyclic factor VIIa inhibitors US Patent  US9174974 Publication Date 11/3/2015
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor VII
Name:Thrombin and coagulation factor VII
Synonyms:Eptacog alfa | Factor VIIa | Factor VIIa (fVIIa) | Proconvertin | SPCA | serum prothrombin conversion accelerator
Type:Enzyme
Mol. Mass.:51599.89
Organism:Homo sapiens (Human)
Description:n/a
Residue:466
Sequence:
MVSQALRLLCLLLGLQGCLAAGGVAKASGGETRDMPWKPGPHRVFVTQEEAHGVLHRRRR
ANAFLEELRPGSLERECKEEQCSFEEAREIFKDAERTKLFWISYSDGDQCASSPCQNGGS
CKDQLQSYICFCLPAFEGRNCETHKDDQLICVNENGGCEQYCSDHTGTKRSCRCHEGYSL
LADGVSCTPTVEYPCGKIPILEKRNASKPQGRIVGGKVCPKGECPWQVLLLVNGAQLCGG
TLINTIWVVSAAHCFDKIKNWRNLIAVLGEHDLSEHDGDEQSRRVAQVIIPSTYVPGTTN
HDIALLRLHQPVVLTDHVVPLCLPERTFSERTLAFVRFSLVSGWGQLLDRGATALELMVL
NVPRLMTQDCLQQSRKVGDSPNITEYMFCAGYSDGSKDSCKGDSGGPHATHYRGTWYLTG
IVSWGQGCATVGHFGVYTRVSQYIEWLQKLMRSEPRPGVLLRAPFP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM189448
n/a
NameBDBM189448
Synonyms:US9174974, Example 34
TypeSmall organic molecule
Emp. Form.C33H35F2N5O5S
Mol. Mass.651.723
SMILESCC(C)S(=O)(=O)c1c(F)cc2NC(=O)OC[C@H](C)c3ccc(cc3C)[C@@H](Nc3cc4ccnc(N)c4cc3F)C(=O)N(C)Cc1c2 |r|
Structure
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