Ki Summary

Reaction Details

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Target

Apoptosis regulator Bcl-2

Ligand

BDBM189508

Substrate/Competitor

n/a

Meas. Tech.

Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) Assay

Temperature

298.15±n/a K

<0.01±n/a nM

Comments

extracted

Citation

Bruncko, M; Ding, H; Doherty, GA; Elmore, SW; Hasvold, LA; Hexamer, L; Kunzer, AR; Song, X; Souers, AJ; Sullivan, GM; Tao, Z; Wang, GT; Wang, L; Wang, X; Wendt, MD; Mantei, RA; Hansen, TM Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases US Patent US9174982 Publication Date 11/3/2015

More Info.:

Get all data from this article, Assay Method

Apoptosis regulator Bcl-2

Name:

Apoptosis regulator Bcl-2

Synonyms:

Type:

Homodimer or heterodimer

Mol. Mass.:

26269.11

Organism:

Homo sapiens (Human)

Description:

P10415

Residue:

239

Sequence:

MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK

BDBM189508

n/a

Name

BDBM189508

Synonyms:

US9174982, 60

Type

Small organic molecule

Emp. Form.

C49H56ClN7O8S

Mol. Mass.

938.529

SMILES

CC1(C)CCC(CN2CCN(CC2)c2ccc(C(=O)NS(=O)(=O)c3ccc(OC4CCC(CC4)N4CCOCC4)c(c3)[N+]([O-])=O)c(Oc3cnc4[nH]ccc4c3)c2)=C(C1)c1ccc(Cl)cc1 |c:63,(8.32,-14.13,;7.51,-12.83,;9.04,-12.88,;7.51,-11.29,;6.17,-10.52,;4.84,-11.29,;3.5,-10.52,;3.5,-8.98,;4.84,-8.21,;4.84,-6.67,;3.5,-5.9,;2.17,-6.67,;2.17,-8.21,;3.5,-4.36,;4.84,-3.59,;4.84,-2.05,;3.5,-1.28,;3.5,.26,;2.17,1.03,;4.84,1.03,;4.84,2.57,;6.38,2.57,;3.3,2.57,;4.84,4.11,;3.5,4.88,;3.5,6.42,;4.84,7.19,;4.84,8.73,;3.5,9.5,;2.17,8.73,;.84,9.5,;.84,11.04,;2.17,11.81,;3.5,11.04,;-.5,11.81,;-1.83,11.04,;-3.16,11.81,;-3.16,13.35,;-1.83,14.12,;-.5,13.35,;6.17,6.42,;6.17,4.88,;7.51,7.19,;7.51,8.73,;8.84,6.42,;2.17,-2.05,;.84,-1.28,;-.5,-2.05,;-.5,-3.59,;-1.83,-4.36,;-3.16,-3.59,;-4.63,-4.06,;-5.53,-2.82,;-4.63,-1.57,;-3.16,-2.05,;-1.83,-1.28,;2.17,-3.59,;4.84,-12.83,;6.17,-13.6,;3.5,-13.6,;3.5,-15.14,;2.17,-15.91,;.84,-15.14,;-.5,-15.91,;.84,-13.6,;2.17,-12.83,)|

Structure