Ki Summary

Reaction Details

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Target

Apoptosis regulator Bcl-2

Ligand

BDBM189519

Substrate/Competitor

n/a

Meas. Tech.

Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) Assay

Temperature

298.15±n/a K

0.01±n/a nM

Comments

extracted

Citation

Bruncko, M; Ding, H; Doherty, GA; Elmore, SW; Hasvold, LA; Hexamer, L; Kunzer, AR; Song, X; Souers, AJ; Sullivan, GM; Tao, Z; Wang, GT; Wang, L; Wang, X; Wendt, MD; Mantei, RA; Hansen, TM Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases US Patent US9174982 Publication Date 11/3/2015

More Info.:

Get all data from this article, Assay Method

Apoptosis regulator Bcl-2

Name:

Apoptosis regulator Bcl-2

Synonyms:

Type:

Homodimer or heterodimer

Mol. Mass.:

26269.11

Organism:

Homo sapiens (Human)

Description:

P10415

Residue:

239

Sequence:

MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK

BDBM189519

n/a

Name

BDBM189519

Synonyms:

US9174982, 71

Type

Small organic molecule

Emp. Form.

C51H59ClN8O7S

Mol. Mass.

963.582

SMILES

[O-][N+](=O)c1cc(ccc1NC1CCC(CC1)N1CCOCC1)S(=O)(=O)NC(=O)c1ccc(cc1Oc1cnc2[nH]ccc2c1)N1CCN(CC2=C(CCC3(CCCC3)C2)c2ccc(Cl)cc2)CC1 |t:55,(5.74,8.89,;4.2,8.89,;3.43,10.22,;3.43,7.55,;4.2,6.22,;3.43,4.89,;1.89,4.89,;1.12,6.22,;1.89,7.55,;1.12,8.89,;-.42,8.89,;-1.19,7.55,;-2.73,7.55,;-3.5,8.89,;-2.73,10.22,;-1.19,10.22,;-5.04,8.89,;-5.81,7.55,;-7.35,7.55,;-8.12,8.89,;-7.35,10.22,;-5.81,10.22,;4.2,3.55,;2.87,2.78,;5.53,4.32,;4.97,2.22,;4.2,.89,;2.66,.89,;4.97,-.45,;4.2,-1.78,;4.97,-3.12,;6.51,-3.12,;7.28,-1.78,;6.51,-.45,;7.28,.89,;8.82,.89,;9.59,2.22,;11.13,2.22,;11.9,.89,;13.41,.57,;13.57,-.97,;12.16,-1.59,;11.13,-.45,;9.59,-.45,;7.28,-4.45,;8.82,-4.45,;9.59,-5.78,;8.82,-7.12,;9.59,-8.45,;8.82,-9.78,;9.59,-11.12,;8.82,-12.45,;7.28,-12.45,;6.51,-11.12,;5.6,-12.36,;4.14,-11.89,;4.14,-10.35,;5.6,-9.87,;7.28,-9.78,;11.13,-11.12,;11.9,-9.78,;13.44,-9.78,;14.21,-11.12,;15.75,-11.12,;13.44,-12.45,;11.9,-12.45,;7.28,-7.12,;6.51,-5.78,)|

Structure