Reaction Details | |||
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Target | Histone-lysine N-methyltransferase EZH2 | ||
Ligand | BDBM190190 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
IC50 | 2.5±n/a nM | ||
Citation | Kuntz, KW; Knutson, SK; Wigle, TJ Inhibitors of human EZH2, and methods of use thereof US Patent US9175331 Publication Date 11/3/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Histone-lysine N-methyltransferase EZH2 | |||
Name: | Histone-lysine N-methyltransferase EZH2 | ||
Synonyms: | ENX-1 | EZH2 | EZH2_HUMAN | Enhancer of zeste homolog 2 (EZH2) | Histone-lysine N-methyltransferase EZH2 | KMT6 | Lysine N-methyltransferase 6 | ||
Type: | Protein | ||
Mol. Mass.: | 85367.84 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q15910 | ||
Residue: | 746 | ||
Sequence: |
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BDBM190190 | |||
n/a | |||
Name | BDBM190190 | ||
Synonyms: | EPZ007648 | US9175331, 18 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H37ClN4O2 | ||
Mol. Mass. | 485.061 | ||
SMILES | CCN([C@H]1CC[C@@H](CC1)N1CCC1)c1cc(Cl)cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,wD:6.9,(-5.33,1.47,;-5.33,-.07,;-4,-.84,;-4,-2.38,;-2.67,-3.15,;-2.67,-4.69,;-4,-5.46,;-5.33,-4.69,;-5.33,-3.15,;-4,-7,;-5.09,-8.08,;-4,-9.17,;-2.91,-8.08,;-2.67,-.07,;-1.33,-.84,;,-.07,;1.33,-.84,;,1.47,;-1.33,2.24,;-1.33,3.78,;-2.67,4.55,;,4.55,;,6.09,;1.33,6.86,;1.33,8.4,;,9.17,;2.67,9.17,;4,8.4,;5.33,9.17,;4,6.86,;2.67,6.09,;2.67,4.55,;-2.67,1.47,;-4,2.24,)| | ||
Structure |