Reaction Details | |||
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Target | Histone-lysine N-methyltransferase EZH2 | ||
Ligand | BDBM172174 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
IC50 | 2.9±n/a nM | ||
Citation | Kuntz, KW; Knutson, SK; Wigle, TJ Inhibitors of human EZH2, and methods of use thereof US Patent US9175331 Publication Date 11/3/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Histone-lysine N-methyltransferase EZH2 | |||
Name: | Histone-lysine N-methyltransferase EZH2 | ||
Synonyms: | ENX-1 | EZH2 | EZH2_HUMAN | Enhancer of zeste homolog 2 (EZH2) | Histone-lysine N-methyltransferase EZH2 | KMT6 | Lysine N-methyltransferase 6 | ||
Type: | Protein | ||
Mol. Mass.: | 85367.84 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q15910 | ||
Residue: | 746 | ||
Sequence: |
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BDBM172174 | |||
n/a | |||
Name | BDBM172174 | ||
Synonyms: | EPZ008681 | US10155002, Compound 182 | US11052093, Compound 182 | US9090562, 182 | US9175331, 44 | ||
Type | Small organic molecule | ||
Emp. Form. | C36H49N5O4 | ||
Mol. Mass. | 615.8054 | ||
SMILES | CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(cc1)C(=O)NCCCO |r,wU:3.2,wD:6.9,(,-4.24,;,-2.7,;-1.33,-1.93,;-2.67,-2.7,;-2.67,-4.23,;-4,-5.01,;-5.33,-4.23,;-5.33,-2.7,;-4,-1.93,;-6.67,-5,;-8,-4.23,;-6.67,-6.54,;-1.33,-.39,;,.38,;,1.92,;-1.33,2.69,;-2.67,1.92,;-4,2.69,;-4,4.23,;-5.33,1.92,;-6.67,2.69,;-8,1.92,;-8,.38,;-6.67,-.39,;-9.34,-.39,;-10.67,.38,;-12,-.39,;-10.67,1.92,;-9.34,2.69,;-9.34,4.23,;-2.67,.38,;-4,-.38,;1.33,2.69,;1.33,4.23,;2.67,5,;4,4.23,;4,2.69,;2.67,1.92,;5.33,5,;5.33,6.54,;6.67,4.23,;8,5,;9.34,4.23,;10.67,5,;12,4.23,)| | ||
Structure |