Ki Summary

Reaction Details

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Target

Histone-lysine N-methyltransferase EZH2

Ligand

BDBM172174

Substrate/Competitor

n/a

Meas. Tech.

Inhibition Assay

IC50

2.9±n/a nM

Citation

Kuntz, KW; Knutson, SK; Wigle, TJ Inhibitors of human EZH2, and methods of use thereof US Patent US9175331 Publication Date 11/3/2015

More Info.:

Get all data from this article, Assay Method

Histone-lysine N-methyltransferase EZH2

Name:

Histone-lysine N-methyltransferase EZH2

Synonyms:

ENX-1 | EZH2 | EZH2_HUMAN | Enhancer of zeste homolog 2 (EZH2) | Histone-lysine N-methyltransferase EZH2 | KMT6 | Lysine N-methyltransferase 6

Type:

Protein

Mol. Mass.:

85367.84

Organism:

Homo sapiens (Human)

Description:

Q15910

Residue:

746

Sequence:

MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
KQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNF
MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ
YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL
KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFH
ATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPN
NSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKM
KPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPA
PAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQ
NFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVS
CKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDK
YMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGE
ELFFDYRYSQADALKYVGIEREMEIP

BDBM172174

n/a

Name

BDBM172174

Synonyms:

EPZ008681 | US10155002, Compound 182 | US11052093, Compound 182 | US9090562, 182 | US9175331, 44

Type

Small organic molecule

Emp. Form.

C36H49N5O4

Mol. Mass.

615.8054

SMILES

CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(cc1)C(=O)NCCCO |r,wU:3.2,wD:6.9,(,-4.24,;,-2.7,;-1.33,-1.93,;-2.67,-2.7,;-2.67,-4.23,;-4,-5.01,;-5.33,-4.23,;-5.33,-2.7,;-4,-1.93,;-6.67,-5,;-8,-4.23,;-6.67,-6.54,;-1.33,-.39,;,.38,;,1.92,;-1.33,2.69,;-2.67,1.92,;-4,2.69,;-4,4.23,;-5.33,1.92,;-6.67,2.69,;-8,1.92,;-8,.38,;-6.67,-.39,;-9.34,-.39,;-10.67,.38,;-12,-.39,;-10.67,1.92,;-9.34,2.69,;-9.34,4.23,;-2.67,.38,;-4,-.38,;1.33,2.69,;1.33,4.23,;2.67,5,;4,4.23,;4,2.69,;2.67,1.92,;5.33,5,;5.33,6.54,;6.67,4.23,;8,5,;9.34,4.23,;10.67,5,;12,4.23,)|

Structure