Reaction Details | |||
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Target | Histone-lysine N-methyltransferase EZH2 [Y641F] | ||
Ligand | BDBM190199 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
IC50 | 2.5±n/a nM | ||
Citation | Kuntz, KW; Knutson, SK; Wigle, TJ Inhibitors of human EZH2, and methods of use thereof US Patent US9175331 Publication Date 11/3/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Histone-lysine N-methyltransferase EZH2 [Y641F] | |||
Name: | Histone-lysine N-methyltransferase EZH2 [Y641F] | ||
Synonyms: | EZH2 | EZH2(Y641F) | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (Y641F) | KMT6 | ||
Type: | n/a | ||
Mol. Mass.: | 85351.84 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q15910[Y641F] | ||
Residue: | 746 | ||
Sequence: |
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BDBM190199 | |||
n/a | |||
Name | BDBM190199 | ||
Synonyms: | EPZ008286 | US9175331, 29 | ||
Type | Small organic molecule | ||
Emp. Form. | C31H42N4O2 | ||
Mol. Mass. | 502.6908 | ||
SMILES | CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C#CC1CC1 |r,wU:3.2,wD:6.9,(-2,5.67,;-3.33,4.9,;-3.33,3.36,;-4.67,2.59,;-4.67,1.05,;-6,.28,;-7.34,1.05,;-7.34,2.59,;-6,3.36,;-8.67,.28,;-10,1.05,;-8.67,-1.26,;-2,2.59,;-2,1.05,;-.67,.28,;.67,1.05,;.67,2.59,;2,3.36,;2,4.9,;3.33,2.59,;4.67,3.36,;6,2.59,;7.34,3.36,;7.34,4.9,;8.67,2.59,;8.67,1.05,;10,.28,;7.34,.28,;6,1.05,;4.67,.28,;-.67,3.36,;-.67,4.9,;-.67,-1.26,;-.67,-2.8,;-.67,-4.34,;-1.44,-5.67,;.1,-5.67,)| | ||
Structure |