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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histone-lysine N-methyltransferase EZH2 [A677G] | ||
| Ligand | BDBM190203 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| IC50 | 1.6±n/a nM | ||
| Citation |  Kuntz, KW; Knutson, SK; Wigle, TJ Inhibitors of human EZH2, and methods of use thereof US Patent US9175331 Publication Date 11/3/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histone-lysine N-methyltransferase EZH2 [A677G] | |||
| Name: | Histone-lysine N-methyltransferase EZH2 [A677G] | ||
| Synonyms: | EZH2 | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (A677G) | KMT6 | ||
| Type: | Protein | ||
| Mol. Mass.: | 85381.87 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15910[A677G] | ||
| Residue: | 746 | ||
| Sequence: |
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| BDBM190203 | |||
| n/a | |||
| Name | BDBM190203 | ||
| Synonyms: | EPZ008344 | US9175331, 34 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C31H44N4O3 | ||
| Mol. Mass. | 520.7061 | ||
| SMILES | CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)C#CC(C)(C)O |r,wU:3.2,wD:6.9,(-5.33,.77,;-5.33,-.77,;-4,-1.54,;-4,-3.08,;-2.67,-3.85,;-2.67,-5.39,;-4,-6.16,;-5.33,-5.39,;-5.33,-3.85,;-4,-7.7,;-2.67,-8.47,;-5.33,-8.47,;-2.67,-.77,;-1.33,-1.54,;,-.77,;,.77,;-1.33,1.54,;-1.33,3.08,;-2.67,3.85,;,3.85,;,5.39,;1.33,6.16,;1.33,7.7,;,8.47,;2.67,8.47,;4,7.7,;5.33,8.47,;4,6.16,;2.67,5.39,;2.67,3.85,;-2.67,.77,;-4,1.54,;1.33,-1.54,;2.67,-2.31,;4,-3.08,;5.33,-3.85,;3.23,-4.41,;4.77,-1.75,)| | ||
| Structure | 
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