Reaction Details | |||
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Target | Histone-lysine N-methyltransferase EZH2 [A687V] | ||
Ligand | BDBM172166 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
IC50 | 3.9±n/a nM | ||
Citation | Kuntz, KW; Knutson, SK; Wigle, TJ Inhibitors of human EZH2, and methods of use thereof US Patent US9175331 Publication Date 11/3/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Histone-lysine N-methyltransferase EZH2 [A687V] | |||
Name: | Histone-lysine N-methyltransferase EZH2 [A687V] | ||
Synonyms: | EZH2 | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (A687V) | KMT6 | ||
Type: | Protein | ||
Mol. Mass.: | 85395.90 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q15910[A687V] | ||
Residue: | 746 | ||
Sequence: |
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BDBM172166 | |||
n/a | |||
Name | BDBM172166 | ||
Synonyms: | EPZ008280 | US10155002, Compound 174 | US11052093, Compound 174 | US9090562, 174 | US9175331, 28 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H40N6O2 | ||
Mol. Mass. | 516.6776 | ||
SMILES | CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1cnccn1 |r,wU:3.2,wD:6.9,(-2,5,;-3.33,4.23,;-3.33,2.69,;-4.67,1.93,;-4.67,.38,;-6,-.38,;-7.34,.38,;-7.34,1.93,;-6,2.69,;-8.67,-.38,;-10,.38,;-8.67,-1.93,;-2,1.93,;-2,.38,;-.67,-.38,;.67,.38,;.67,1.93,;2,2.69,;2,4.23,;3.33,1.93,;4.67,2.69,;6,1.93,;7.34,2.69,;7.34,4.23,;8.67,1.93,;8.67,.38,;10,-.38,;7.34,-.38,;6,.38,;4.67,-.38,;-.67,2.69,;-.67,4.23,;-.67,-1.93,;-2,-2.69,;-2,-4.23,;-.67,-5,;.67,-4.23,;.67,-2.69,)| | ||
Structure |