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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Histone-lysine N-methyltransferase EZH2 [A687V] | ||
| Ligand | BDBM172167 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| IC50 | 7.2±n/a nM | ||
| Citation |  Kuntz, KW; Knutson, SK; Wigle, TJ Inhibitors of human EZH2, and methods of use thereof US Patent US9175331 Publication Date 11/3/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Histone-lysine N-methyltransferase EZH2 [A687V] | |||
| Name: | Histone-lysine N-methyltransferase EZH2 [A687V] | ||
| Synonyms: | EZH2 | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (A687V) | KMT6 | ||
| Type: | Protein | ||
| Mol. Mass.: | 85395.90 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15910[A687V] | ||
| Residue: | 746 | ||
| Sequence: |
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| BDBM172167 | |||
| n/a | |||
| Name | BDBM172167 | ||
| Synonyms: | EPZ008338 | US10155002, Compound 175 | US11052093, Compound 175 | US9090562, 175 | US9175331, 33 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C31H42N6O2 | ||
| Mol. Mass. | 530.7042 | ||
| SMILES | CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1cnc(C)cn1 |r,wU:3.2,wD:6.9,(-2,5.78,;-3.33,5,;-3.33,3.47,;-4.67,2.69,;-4.67,1.15,;-6,.38,;-7.34,1.15,;-7.34,2.69,;-6,3.47,;-8.67,.38,;-10,1.15,;-8.67,-1.15,;-2,2.69,;-2,1.15,;-.67,.38,;.67,1.15,;.67,2.69,;2,3.47,;2,5,;3.33,2.69,;4.67,3.47,;6,2.69,;7.34,3.47,;7.34,5,;8.67,2.69,;8.67,1.15,;10,.38,;7.34,.38,;6,1.15,;4.67,.38,;-.67,3.47,;-.67,5,;-.67,-1.15,;-2,-1.93,;-2,-3.47,;-.67,-4.23,;-.67,-5.78,;.67,-3.47,;.67,-1.93,)| | ||
| Structure | 
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