Reaction Details | |||
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Target | Histone-lysine N-methyltransferase EZH2 [A687V] | ||
Ligand | BDBM190209 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
IC50 | 9.6±n/a nM | ||
Citation | Kuntz, KW; Knutson, SK; Wigle, TJ Inhibitors of human EZH2, and methods of use thereof US Patent US9175331 Publication Date 11/3/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Histone-lysine N-methyltransferase EZH2 [A687V] | |||
Name: | Histone-lysine N-methyltransferase EZH2 [A687V] | ||
Synonyms: | EZH2 | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (A687V) | KMT6 | ||
Type: | Protein | ||
Mol. Mass.: | 85395.90 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q15910[A687V] | ||
Residue: | 746 | ||
Sequence: |
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BDBM190209 | |||
n/a | |||
Name | BDBM190209 | ||
Synonyms: | EPZ008686 | US9175331, 45 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H39BrN4O2 | ||
Mol. Mass. | 531.528 | ||
SMILES | CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(Br)c(C)c(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C |r,wU:3.2,wD:6.9,(-5.33,.77,;-5.33,-.77,;-4,-1.54,;-4,-3.08,;-2.67,-3.85,;-2.67,-5.39,;-4,-6.16,;-5.33,-5.39,;-5.33,-3.85,;-4,-7.7,;-2.67,-8.47,;-5.33,-8.47,;-2.67,-.77,;-1.33,-1.54,;,-.77,;1.33,-1.54,;,.77,;1.33,1.54,;-1.33,1.54,;-1.33,3.08,;-2.67,3.85,;,3.85,;,5.39,;1.33,6.16,;1.33,7.7,;,8.47,;2.67,8.47,;4,7.7,;5.33,8.47,;4,6.16,;2.67,5.39,;2.67,3.85,;-2.67,.77,;-4,1.54,)| | ||
Structure |