Reaction Details |
| Report a problem with these data |
Target | Prostaglandin E2 receptor EP4 subtype |
---|
Ligand | BDBM190275 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Radioligand Binding Assay |
---|
pH | 6±n/a |
---|
Ki | 0.28±n/a nM |
---|
IC50 | 0.74±n/a nM |
---|
Comments | extracted |
---|
Citation | Barrett, SD; Ciske, FL; Colombo, JM; Endres, GW; Germain, BD; Kornilov, A; Kramer, JB; Uzieblo, A; Maxey, KM Difluorolactam compounds as EP4 receptor-selective agonists for use in the treatment of EP4-mediated diseases and conditions US Patent US9180116 Publication Date 11/10/2015 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Prostaglandin E2 receptor EP4 subtype |
---|
Name: | Prostaglandin E2 receptor EP4 subtype |
Synonyms: | PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor |
Type: | Enzyme |
Mol. Mass.: | 53134.53 |
Organism: | Homo sapiens (Human) |
Description: | P35408 |
Residue: | 488 |
Sequence: | MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCG
LAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLA
INHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTA
HAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRG
HPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQP
SLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSG
QHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPG
MGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSET
LNLSEKCI
|
|
|
BDBM190275 |
---|
n/a |
---|
Name | BDBM190275 |
Synonyms: | US9180116, 28C | US9180116, 28H |
Type | Small organic molecule |
Emp. Form. | C26H31F2NO4S |
Mol. Mass. | 491.59 |
SMILES | C[C@@H](CCCc1ccccc1)[C@H](O)\C=C\[C@H]1CC(F)(F)C(=O)N1CCCc1ccc(s1)C(O)=O |
Structure |
|