| Reaction Details |
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 | Report a problem with these data |
| Target | Enoyl-[acyl-carrier-protein] reductase [NADH] [T276S] |
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| Ligand | BDBM190653 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Kinetics |
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| IC50 | 2e+3±n/a nM |
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| Citation |  Neckles, C; Pschibul, A; Lai, CT; Hirschbeck, M; Kuper, J; Davoodi, S; Zou, J; Liu, N; Pan, P; Shah, S; Daryaee, F; Bommineni, GR; Lai, C; Simmerling, C; Kisker, C; Tonge, PJ Selectivity of Pyridone- and Diphenyl Ether-Based Inhibitors for the Yersinia pestis FabV Enoyl-ACP Reductase. Biochemistry55:2992-3006 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Enoyl-[acyl-carrier-protein] reductase [NADH] [T276S] |
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| Name: | Enoyl-[acyl-carrier-protein] reductase [NADH] [T276S] |
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| Synonyms: | Enoyl-ACP reductase T276S (T276S ypFabV) | FABV_YERPY | fabV |
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| Type: | Protein |
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| Mol. Mass.: | 43321.97 |
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| Organism: | Yersinia pestis (Enterobacteria) |
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| Description: | B1JRQ0[T276S] |
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| Residue: | 399 |
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| Sequence: | MIIKPRVRGFICVTAHPTGCEANVKKQIDYVTTEGPIANGPKRVLVIGASTGYGLAARIT
AAFGCGADTLGVFFERPGEEGKPGTSGWYNSAAFHKFAAQKGLYAKSINGDAFSDEIKQL
TIDAIKQDLGQVDQVIYSLASPRRTHPKTGEVFNSALKPIGNAVNLRGLDTDKEVIKESV
LQPATQSEIDSTVAVMGGEDWQMWIDALLDAGVLAEGAQTTAFTYLGEKITHDIYWNGSI
GAAKKDLDQKVLAIRESLAAHGGGDARVSVLKAVVSQASSAIPMMPLYLSLLFKVMKEKG
THEGCIEQVYSLYKDSLCGDSPHMDQEGRLRADYKELDPEVQNQVQQLWDQVTNDNIYQL
TDFVGYKSEFLNLFGFGIDGVDYDADVNPDVKIPNLIQG
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| BDBM190653 |
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| n/a |
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| Name | BDBM190653 |
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| Synonyms: | PT172 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H22ClNO |
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| Mol. Mass. | 303.826 |
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| SMILES | CCCCCCc1ccn(Cc2ccccc2Cl)c(=O)c1 |
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| Structure | 
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