| Reaction Details |
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 | Report a problem with these data |
| Target | Arachidonate 15-lipoxygenase |
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| Ligand | BDBM21383 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | LoxA HTP Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 1.14e+4± 1.9e+3 nM |
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| Comments | extracted |
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| Citation |  Deschamps, JD; Ogunsola, AF; Jameson, JB; Yasgar, A; Flitter, BA; Freedman, CJ; Melvin, JA; Nguyen, JV; Maloney, DJ; Jadhav, A; Simeonov, A; Bomberger, JM; Holman, TR Biochemical and Cellular Characterization and Inhibitor Discovery of Pseudomonas aeruginosa 15-Lipoxygenase. Biochemistry55:3329-40 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Arachidonate 15-lipoxygenase |
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| Name: | Arachidonate 15-lipoxygenase |
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| Synonyms: | 15-Lipoxygenase (LoxA) |
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| Type: | Protein |
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| Mol. Mass.: | 74804.41 |
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| Organism: | Pseudomonas aeruginosa |
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| Description: | n/a |
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| Residue: | 685 |
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| Sequence: | MKRRSVLLSGVALSGTALANDSIFFSPLKYLGAEQQRSIDASRSLLDNLIPPSLPQYDNL
AGKLARRAVLTSKKLVYVWTENFGNVKGVPMARSVPLGELPNVDWLLKTAGVIVELIVNF
VASLPASAAAQFERIATGLSGDLEAARQVHEALLEEAKNDPAAAGSLLLRFTELQTRVIA
ILTRVGLLVDDILKSASNLVTQRGQGDGLNRFRAVFGTLRLPEVADSFRDDEAFAYWRVA
GPNPLLIRRVDALPANFPLGEEQFRRVMGADDSLLEAAASRRLYLLDYAELGKLAPSGAV
DKLLTGTGFAYAPIALFALGKDRARLLPVAIQCGQDPATHPMFVRPAESESDLYWGWQMA
KTVVQVAEENYHEMFVHLAQTHLVSEAFCLATQRTLAPSHPLHVLLAPHFEGTLFINEGA
ARILLPSAGFIDVMFAAPIQDTQATAGGNRLGFDFYRGMLPESLKARNVDDPLALPDYPY
RDDGLLVWNAIRQWAADYVAVYYASDGDVTADVELAAWVGEVIGSGKVAGFRPITGRSQL
VEVLTMVIFTASAQHAAVNFPQPSMMTYAPAICAMSAAPAPDSPSGKSEADWLKMMPPTL
VALEKVNIYHLLGSVYHGRLGDYRQTGFPYAPVFSDRRVTASGGPLERFQARLKEVEATI
RTRNQARRRPYEYLLPSRIPASTNI
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| BDBM21383 |
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| n/a |
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| Name | BDBM21383 |
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| Synonyms: | 6-[4-(2-phenylphenyl)piperazin-1-yl]-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide | NCGC00186032 | Piperazinehexanamide derivative, 21 |
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| Type | Small organic molecule |
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| Emp. Form. | C32H39N3O |
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| Mol. Mass. | 481.6716 |
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| SMILES | O=C(CCCCCN1CCN(CC1)c1ccccc1-c1ccccc1)NC1CCCc2ccccc12 |
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| Structure | 
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