| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase BRSK1 |
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| Ligand | BDBM191572 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Radiometric-Based Assay (Epiblastin A) |
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| IC50 | 2.42e+4± 5.8e+3 nM |
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| Citation |  Ursu, A; Illich, DJ; Takemoto, Y; Porfetye, AT; Zhang, M; Brockmeyer, A; Janning, P; Watanabe, N; Osada, H; Vetter, IR; Ziegler, S; Schöler, HR; Waldmann, H Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1. Cell Chem Biol23:494-507 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase BRSK1 |
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| Name: | Serine/threonine-protein kinase BRSK1 |
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| Synonyms: | BR serine/threonine-protein kinase 1 | BRSK1 | BRSK1_HUMAN | KIAA1811 | SAD1 | SADB | Serine/threonine-protein kinase BRSK1 (BRSK1) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 85119.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_24308326 |
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| Residue: | 778 |
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| Sequence: | MSSGAKEGGGGSPAYHLPHPHPHPPQHAQYVGPYRLEKTLGKGQTGLVKLGVHCITGQKV
AIKIVNREKLSESVLMKVEREIAILKLIEHPHVLKLHDVYENKKYLYLVLEHVSGGELFD
YLVKKGRLTPKEARKFFRQIVSALDFCHSYSICHRDLKPENLLLDEKNNIRIADFGMASL
QVGDSLLETSCGSPHYACPEVIKGEKYDGRRADMWSCGVILFALLVGALPFDDDNLRQLL
EKVKRGVFHMPHFIPPDCQSLLRGMIEVEPEKRLSLEQIQKHPWYLGGKHEPDPCLEPAP
GRRVAMRSLPSNGELDPDVLESMASLGCFRDRERLHRELRSEEENQEKMIYYLLLDRKER
YPSCEDQDLPPRNDVDPPRKRVDSPMLSRHGKRRPERKSMEVLSITDAGGGGSPVPTRRA
LEMAQHSQRSRSVSGASTGLSSSPLSSPRSPVFSFSPEPGAGDEARGGGSPTSKTQTLPS
RGPRGGGAGEQPPPPSARSTPLPGPPGSPRSSGGTPLHSPLHTPRASPTGTPGTTPPPSP
GGGVGGAAWRSRLNSIRNSFLGSPRFHRRKMQVPTAEEMSSLTPESSPELAKRSWFGNFI
SLDKEEQIFLVLKDKPLSSIKADIVHAFLSIPSLSHSVLSQTSFRAEYKASGGPSVFQKP
VRFQVDISSSEGPEPSPRRDGSGGGGIYSVTFTLISGPSRRFKRVVETIQAQLLSTHDQP
SVQALADEKNGAQTRPAGAPPRSLQPPPGRPDPELSSSPRRGPPKDKKLLATNGTPLP
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| BDBM191572 |
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| n/a |
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| Name | BDBM191572 |
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| Synonyms: | 6-(3-chlorophenyl)pteridine-2,4,7-triamine (15) | Epiblastin A |
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| Type | Small organic molecule |
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| Emp. Form. | C12H10ClN7 |
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| Mol. Mass. | 287.708 |
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| SMILES | Nc1nc(N)c2nc(c(N)nc2n1)-c1cccc(Cl)c1 |
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| Structure | 
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