| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lysine-specific demethylase 5A [1-739] |
|---|
| Ligand | BDBM191598 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Formaldehyde Dehydrogenase-Coupled Demethylase (FDH) Assay |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 4.8e+3± 8e+2 nM |
|---|
| Comments | extracted |
|---|
| Citation |  Horton, JR; Liu, X; Gale, M; Wu, L; Shanks, JR; Zhang, X; Webber, PJ; Bell, JS; Kales, SC; Mott, BT; Rai, G; Jansen, DJ; Henderson, MJ; Urban, DJ; Hall, MD; Simeonov, A; Maloney, DJ; Johns, MA; Fu, H; Jadhav, A; Vertino, PM; Yan, Q; Cheng, X Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol23:769-81 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lysine-specific demethylase 5A [1-739] |
|---|
| Name: | Lysine-specific demethylase 5A [1-739] |
|---|
| Synonyms: | JARID1A | KDM5A | KDM5A_HUMAN | Lysine-specific demethylase 5A (KDM5A(aa 1-739)-AP(2C-2S)) | RBBP2 | RBP2 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 84420.66 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Truncation 1-739 aa. Contains deletion of ARID and PhD1 domains. |
|---|
| Residue: | 739 |
|---|
| Sequence: | MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPP
FACEVKSFRFTPRVQRLNELEAMTRVRLDFLDQLAKFWELQGSTLKIPVVERKILDLYAL
SKIVASKGGFEMVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMG
VQMPNLDLKEKVEPEVLSTDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSRNTELKKLQ
IFGAGPKVVGLAMGTKDKEDEVTRRRKVTNRSDAFNMQMRQRKGTLSVNFVDLYVCMFCG
RGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFEQAVRE
YTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGS
GFPVKDGRRKILPEEEEYALSGWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSF
CWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIM
NPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVN
HYRRLRRHCVFSHEELIFKMAADPECLDVGLAAMVCKELTLMTEEETRLRESVVQMGVLM
SEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRY
PLEDLPSLLYGVKVRAQSY
|
|
|
|---|
| BDBM191598 |
|---|
| n/a |
|---|
| Name | BDBM191598 |
|---|
| Synonyms: | 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinic acid (KDM5-C49) | KDM5-C49 | KDOAM-20 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H24N4O3 |
|---|
| Mol. Mass. | 308.3761 |
|---|
| SMILES | CCN(CCN(C)C)C(=O)CNCc1cc(ccn1)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
