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TargetLysine-specific demethylase 5A [1-739]
LigandBDBM191601
Substrate/Competitorn/a
Meas. Tech.Formaldehyde Dehydrogenase-Coupled Demethylase (FDH) Assay
Temperature298.15±n/a K
IC50 7e+3± 2e+3 nM
Commentsextracted
Citation Horton, JRLiu, XGale, MWu, LShanks, JRZhang, XWebber, PJBell, JSKales, SCMott, BTRai, GJansen, DJHenderson, MJUrban, DJHall, MDSimeonov, AMaloney, DJJohns, MAFu, HJadhav, AVertino, PMYan, QCheng, X Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol23:769-81 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lysine-specific demethylase 5A [1-739]
Name:Lysine-specific demethylase 5A [1-739]
Synonyms:JARID1A | KDM5A | KDM5A_HUMAN | Lysine-specific demethylase 5A (KDM5A(aa 1-739)-AP(2C-2S)) | RBBP2 | RBP2
Type:Protein
Mol. Mass.:84420.66
Organism:Homo sapiens (Human)
Description:Truncation 1-739 aa. Contains deletion of ARID and PhD1 domains.
Residue:739
Sequence:
MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPP
FACEVKSFRFTPRVQRLNELEAMTRVRLDFLDQLAKFWELQGSTLKIPVVERKILDLYAL
SKIVASKGGFEMVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMG
VQMPNLDLKEKVEPEVLSTDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSRNTELKKLQ
IFGAGPKVVGLAMGTKDKEDEVTRRRKVTNRSDAFNMQMRQRKGTLSVNFVDLYVCMFCG
RGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFEQAVRE
YTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGS
GFPVKDGRRKILPEEEEYALSGWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSF
CWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIM
NPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVN
HYRRLRRHCVFSHEELIFKMAADPECLDVGLAAMVCKELTLMTEEETRLRESVVQMGVLM
SEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRY
PLEDLPSLLYGVKVRAQSY
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BDBM191601
n/a
NameBDBM191601
Synonyms:3-(2-(4-chlorophenyl)acetamido)isonicotinic acid (N16)
TypeSmall organic molecule
Emp. Form.C14H11ClN2O3
Mol. Mass.290.702
SMILESOC(=O)c1ccncc1NC(=O)Cc1ccc(Cl)cc1
Structure
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