Reaction Details |
| Report a problem with these data |
Target | Lysine-specific demethylase 5A [1-739] |
---|
Ligand | BDBM191601 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Formaldehyde Dehydrogenase-Coupled Demethylase (FDH) Assay |
---|
Temperature | 298.15±n/a K |
---|
IC50 | 7e+3± 2e+3 nM |
---|
Comments | extracted |
---|
Citation | Horton, JR; Liu, X; Gale, M; Wu, L; Shanks, JR; Zhang, X; Webber, PJ; Bell, JS; Kales, SC; Mott, BT; Rai, G; Jansen, DJ; Henderson, MJ; Urban, DJ; Hall, MD; Simeonov, A; Maloney, DJ; Johns, MA; Fu, H; Jadhav, A; Vertino, PM; Yan, Q; Cheng, X Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol23:769-81 (2016) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Lysine-specific demethylase 5A [1-739] |
---|
Name: | Lysine-specific demethylase 5A [1-739] |
Synonyms: | JARID1A | KDM5A | KDM5A_HUMAN | Lysine-specific demethylase 5A (KDM5A(aa 1-739)-AP(2C-2S)) | RBBP2 | RBP2 |
Type: | Protein |
Mol. Mass.: | 84420.66 |
Organism: | Homo sapiens (Human) |
Description: | Truncation 1-739 aa. Contains deletion of ARID and PhD1 domains. |
Residue: | 739 |
Sequence: | MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPP
FACEVKSFRFTPRVQRLNELEAMTRVRLDFLDQLAKFWELQGSTLKIPVVERKILDLYAL
SKIVASKGGFEMVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMG
VQMPNLDLKEKVEPEVLSTDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSRNTELKKLQ
IFGAGPKVVGLAMGTKDKEDEVTRRRKVTNRSDAFNMQMRQRKGTLSVNFVDLYVCMFCG
RGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFEQAVRE
YTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGS
GFPVKDGRRKILPEEEEYALSGWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSF
CWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIM
NPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVN
HYRRLRRHCVFSHEELIFKMAADPECLDVGLAAMVCKELTLMTEEETRLRESVVQMGVLM
SEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRY
PLEDLPSLLYGVKVRAQSY
|
|
|
BDBM191601 |
---|
n/a |
---|
Name | BDBM191601 |
Synonyms: | 3-(2-(4-chlorophenyl)acetamido)isonicotinic acid (N16) |
Type | Small organic molecule |
Emp. Form. | C14H11ClN2O3 |
Mol. Mass. | 290.702 |
SMILES | OC(=O)c1ccncc1NC(=O)Cc1ccc(Cl)cc1 |
Structure |
|