Reaction Details |
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Target | Lysine-specific demethylase 5B [1-755] |
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Ligand | BDBM191599 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Formaldehyde Dehydrogenase-Coupled Demethylase (FDH) Assay |
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Temperature | 298.15±n/a K |
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IC50 | 3.1e+4± 2e+3 nM |
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Comments | extracted |
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Citation | Horton, JR; Liu, X; Gale, M; Wu, L; Shanks, JR; Zhang, X; Webber, PJ; Bell, JS; Kales, SC; Mott, BT; Rai, G; Jansen, DJ; Henderson, MJ; Urban, DJ; Hall, MD; Simeonov, A; Maloney, DJ; Johns, MA; Fu, H; Jadhav, A; Vertino, PM; Yan, Q; Cheng, X Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol23:769-81 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Lysine-specific demethylase 5B [1-755] |
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Name: | Lysine-specific demethylase 5B [1-755] |
Synonyms: | JARID1B | KDM5B | KDM5B_HUMAN | Lysine-specific demethylase 5B (KDM5B(aa 1-755)-AP) | PLU1 | RBBP2H1 |
Type: | Protein |
Mol. Mass.: | 86559.22 |
Organism: | Homo sapiens (Human) |
Description: | Truncation 1-755 aa. Contains deletion of ARID and PhD1 domains. |
Residue: | 755 |
Sequence: | MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTG
ICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNFLDQIAKYWELQGSTLKI
PHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILN
PYNLFLSGDSLRCLQKPNLTTDTKDKEYKPHDIPQRQSVQPSETCPPARRAKRMRAEAMN
IKIEPEETTEARTHNLRRRMGCPTPKCENEKEMKSSIKQEPIERKDYIVENEKEKPKSRS
KKATNAVDLYVCLLCGSGNDEDRLLLCDGCDDSYHTFCLIPPLHDVPKGDWRCPKCLAQE
CSKPQEAFGFEQAARDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEED
VTVEYGADIASKEFGSGFPVRDGKIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADIC
GMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPE
LFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAV
NFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIE
DEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVK
ELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAESY
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BDBM191599 |
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n/a |
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Name | BDBM191599 |
Synonyms: | KDOAM-21 | ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate (KDM5-C70) |
Type | Small organic molecule |
Emp. Form. | C17H28N4O3 |
Mol. Mass. | 336.4292 |
SMILES | CCOC(=O)c1ccnc(CNCC(=O)N(CC)CCN(C)C)c1 |
Structure |
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