| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific demethylase 5D [1-760] |
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| Ligand | BDBM191599 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Formaldehyde Dehydrogenase-Coupled Demethylase (FDH) Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 2.90e+5± 4.0e+4 nM |
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| Comments | extracted |
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| Citation |  Horton, JR; Liu, X; Gale, M; Wu, L; Shanks, JR; Zhang, X; Webber, PJ; Bell, JS; Kales, SC; Mott, BT; Rai, G; Jansen, DJ; Henderson, MJ; Urban, DJ; Hall, MD; Simeonov, A; Maloney, DJ; Johns, MA; Fu, H; Jadhav, A; Vertino, PM; Yan, Q; Cheng, X Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol23:769-81 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific demethylase 5D [1-760] |
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| Name: | Lysine-specific demethylase 5D [1-760] |
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| Synonyms: | HY | HYA | JARID1D | KDM5D | KDM5D_HUMAN | KIAA0234 | Lysine-specific demethylase 5D (KDM5D(aa 1-760)-AP) | SMCY |
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| Type: | Protein |
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| Mol. Mass.: | 87351.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Truncation 1-760 aa. Contains deletion of ARID and PhD1 domains. |
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| Residue: | 760 |
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| Sequence: | MEPGCDEFLPPPECPVFEPSWAEFQDPLGYIAKIRPIAEKSGICKIRPPADWQPPFAVEV
DNFRFTPRVQRLNELEAQTRVKLNYLDQIAKFWEIQGSSLKIPNVERKILDLYSLSKIVI
EEGGYEAICKDRRWARVAQRLHYPPGKNIGSLLRSHYERIIYPYEMFQSGANHVQCNTHP
FDNEVKDKEYKPHSIPLRQSVQPSKFSSYSRRAKRLQPDPEPTEEDIEKHPELKKLQIYG
PGPKMMGLGLMAKDKDKTVHKKVTCPPTVTVKDEQSGGGNVSSTLLKQHLSLEPCTKTTM
QLRKNHSSAQFIDSYICQVCSRGDEDDKLLFCDGCDDNYHIFCLLPPLPEIPRGIWRCPK
CILAECKQPPEAFGFEQATQEYSLQSFGEMADSFKSDYFNMPVHMVPTELVEKEFWRLVS
SIEEDVTVEYGADIHSKEFGSGFPVSNSKQNLSPEEKEYATSGWNLNVMPVLDQSVLCHI
NADISGMKVPWLYVGMVFSAFCWHIEDHWSYSINYLHWGEPKTWYGVPSLAAEHLEEVMK
MLTPELFDSQPDLLHQLVTLMNPNTLMSHGVPVVRTNQCAGEFVITFPRAYHSGFNQGYN
FAEAVNFCTADWLPAGRQCIEHYRRLRRYCVFSHEELICKMAAFPETLDLNLAVAVHKEM
FIMVQEERRLRKALLEKGVTEAEREAFELLPDDERQCIKCKTTCFLSALACYDCPDGLVC
LSHINDLCKCSSSRQYLRYRYTLDELPTMLHKLKIRAESF
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| BDBM191599 |
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| n/a |
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| Name | BDBM191599 |
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| Synonyms: | KDOAM-21 | ethyl 2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-oxoethyl)amino)methyl)isonicotinate (KDM5-C70) |
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| Type | Small organic molecule |
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| Emp. Form. | C17H28N4O3 |
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| Mol. Mass. | 336.4292 |
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| SMILES | CCOC(=O)c1ccnc(CNCC(=O)N(CC)CCN(C)C)c1 |
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| Structure | 
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