| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific demethylase 5B [1-755] |
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| Ligand | BDBM191604 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Formaldehyde Dehydrogenase-Coupled Demethylase (FDH) Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | >3.2e+4±n/a nM |
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| Comments | extracted |
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| Citation |  Horton, JR; Liu, X; Gale, M; Wu, L; Shanks, JR; Zhang, X; Webber, PJ; Bell, JS; Kales, SC; Mott, BT; Rai, G; Jansen, DJ; Henderson, MJ; Urban, DJ; Hall, MD; Simeonov, A; Maloney, DJ; Johns, MA; Fu, H; Jadhav, A; Vertino, PM; Yan, Q; Cheng, X Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol23:769-81 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific demethylase 5B [1-755] |
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| Name: | Lysine-specific demethylase 5B [1-755] |
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| Synonyms: | JARID1B | KDM5B | KDM5B_HUMAN | Lysine-specific demethylase 5B (KDM5B(aa 1-755)-AP) | PLU1 | RBBP2H1 |
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| Type: | Protein |
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| Mol. Mass.: | 86559.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Truncation 1-755 aa. Contains deletion of ARID and PhD1 domains. |
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| Residue: | 755 |
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| Sequence: | MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTG
ICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNFLDQIAKYWELQGSTLKI
PHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILN
PYNLFLSGDSLRCLQKPNLTTDTKDKEYKPHDIPQRQSVQPSETCPPARRAKRMRAEAMN
IKIEPEETTEARTHNLRRRMGCPTPKCENEKEMKSSIKQEPIERKDYIVENEKEKPKSRS
KKATNAVDLYVCLLCGSGNDEDRLLLCDGCDDSYHTFCLIPPLHDVPKGDWRCPKCLAQE
CSKPQEAFGFEQAARDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEED
VTVEYGADIASKEFGSGFPVRDGKIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADIC
GMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPE
LFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAV
NFCTVDWLPLGRQCVEHYRLLHRYCVFSHDEMICKMASKADVLDVVVASTVQKDMAIMIE
DEKALRETVRKLGVIDSERMDFELLPDDERQCVKCKTTCFMSAISCSCKPGLLVCLHHVK
ELCSCPPYKYKLRYRYTLDDLYPMMNALKLRAESY
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| BDBM191604 |
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| n/a |
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| Name | BDBM191604 |
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| Synonyms: | 8-(1-methyl-1Himidazol-4-yl)-2-(4,4,4-trifluorobutoxy)pyrido[3,4-d]pyrimidin-4-ol (N10) |
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| Type | Small organic molecule |
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| Emp. Form. | C15H14F3N5O2 |
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| Mol. Mass. | 353.2992 |
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| SMILES | Cn1cnc(c1)-c1nccc2c(O)nc(OCCCC(F)(F)F)nc12 |
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| Structure | 
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