| Reaction Details |
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 | Report a problem with these data |
| Target | Lysine-specific demethylase 5A [1-588] |
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| Ligand | BDBM191596 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Isothermal Titration Calorimetry (ITC) |
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| Kd | 27± 6 nM |
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| Citation |  Horton, JR; Liu, X; Gale, M; Wu, L; Shanks, JR; Zhang, X; Webber, PJ; Bell, JS; Kales, SC; Mott, BT; Rai, G; Jansen, DJ; Henderson, MJ; Urban, DJ; Hall, MD; Simeonov, A; Maloney, DJ; Johns, MA; Fu, H; Jadhav, A; Vertino, PM; Yan, Q; Cheng, X Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol23:769-81 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Lysine-specific demethylase 5A [1-588] |
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| Name: | Lysine-specific demethylase 5A [1-588] |
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| Synonyms: | JARID1A | KDM5A | KDM5A_HUMAN | Lysine-specific demethylase 5A (KDM5A(aa 1-588)-AP) | RBBP2 | RBP2 |
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| Type: | Protein |
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| Mol. Mass.: | 66955.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Truncation 1-588 aa. Contains deletion of ARID and PhD1 domains. |
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| Residue: | 588 |
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| Sequence: | MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPP
FACEVKSFRFTPRVQRLNELEAMTRVRLDFLDQLAKFWELQGSTLKIPVVERKILDLYAL
SKIVASKGGFEMVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMG
VQMPNLDLKEKVEPEVLSTDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSRNTELKKLQ
IFGAGPKVVGLAMGTKDKEDEVTRRRKVTNRSDAFNMQMRQRKGTLSVNFVDLYVCMFCG
RGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFEQAVRE
YTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGS
GFPVKDGRRKILPEEEEYALSGWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSF
CWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIM
NPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCT
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| BDBM191596 |
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| n/a |
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| Name | BDBM191596 |
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| Synonyms: | 6-isopropyl-5-methyl-7-oxo-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carbonitrile (N8) |
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| Type | Small organic molecule |
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| Emp. Form. | C11H12N4O |
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| Mol. Mass. | 216.2392 |
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| SMILES | CC(C)c1c(C)[nH]c2c(cnn2c1=O)C#N |
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| Structure | 
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