| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Lysine-specific demethylase 5B [1-604] |
|---|
| Ligand | BDBM191604 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Isothermal Titration Calorimetry (ITC) |
|---|
| Kd | >3.0e+4±n/a nM |
|---|
| Citation |  Horton, JR; Liu, X; Gale, M; Wu, L; Shanks, JR; Zhang, X; Webber, PJ; Bell, JS; Kales, SC; Mott, BT; Rai, G; Jansen, DJ; Henderson, MJ; Urban, DJ; Hall, MD; Simeonov, A; Maloney, DJ; Johns, MA; Fu, H; Jadhav, A; Vertino, PM; Yan, Q; Cheng, X Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol23:769-81 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Lysine-specific demethylase 5B [1-604] |
|---|
| Name: | Lysine-specific demethylase 5B [1-604] |
|---|
| Synonyms: | JARID1B | KDM5B | KDM5B_HUMAN | Lysine-specific demethylase 5B (KDM5B(aa 1-604)-AP) | PLU1 | RBBP2H1 |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 68980.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Truncation 1-604 aa. Contains deletion of ARID and PhD1 domains. |
|---|
| Residue: | 604 |
|---|
| Sequence: | MEAATTLHPGPRPALPLGGPGPLGEFLPPPECPVFEPSWEEFADPFAFIHKIRPIAEQTG
ICKVRPPPDWQPPFACDVDKLHFTPRIQRLNELEAQTRVKLNFLDQIAKYWELQGSTLKI
PHVERKILDLFQLNKLVAEEGGFAVVCKDRKWTKIATKMGFAPGKAVGSHIRGHYERILN
PYNLFLSGDSLRCLQKPNLTTDTKDKEYKPHDIPQRQSVQPSETCPPARRAKRMRAEAMN
IKIEPEETTEARTHNLRRRMGCPTPKCENEKEMKSSIKQEPIERKDYIVENEKEKPKSRS
KKATNAVDLYVCLLCGSGNDEDRLLLCDGCDDSYHTFCLIPPLHDVPKGDWRCPKCLAQE
CSKPQEAFGFEQAARDYTLRTFGEMADAFKSDYFNMPVHMVPTELVEKEFWRLVSTIEED
VTVEYGADIASKEFGSGFPVRDGKIKLSPEEEEYLDSGWNLNNMPVMEQSVLAHITADIC
GMKLPWLYVGMCFSSFCWHIEDHWSYSINYLHWGEPKTWYGVPGYAAEQLENVMKKLAPE
LFVSQPDLLHQLVTIMNPNTLMTHEVPVYRTNQCAGEFVITFPRAYHSGFNQGFNFAEAV
NFCT
|
|
|
|---|
| BDBM191604 |
|---|
| n/a |
|---|
| Name | BDBM191604 |
|---|
| Synonyms: | 8-(1-methyl-1Himidazol-4-yl)-2-(4,4,4-trifluorobutoxy)pyrido[3,4-d]pyrimidin-4-ol (N10) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H14F3N5O2 |
|---|
| Mol. Mass. | 353.2992 |
|---|
| SMILES | Cn1cnc(c1)-c1nccc2c(O)nc(OCCCC(F)(F)F)nc12 |
|---|
| Structure | 
|
|---|
Search and Browse
