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TargetLysine-specific demethylase 5A [1-1090]
LigandBDBM191600
Substrate/Competitorn/a
Meas. Tech.AlphaLISA Assay
pH7.2±n/a
Temperature298.15±n/a K
IC50 2.4e+2± 1e+1 nM
Commentsextracted
Citation Horton, JRLiu, XGale, MWu, LShanks, JRZhang, XWebber, PJBell, JSKales, SCMott, BTRai, GJansen, DJHenderson, MJUrban, DJHall, MDSimeonov, AMaloney, DJJohns, MAFu, HJadhav, AVertino, PMYan, QCheng, X Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chem Biol23:769-81 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lysine-specific demethylase 5A [1-1090]
Name:Lysine-specific demethylase 5A [1-1090]
Synonyms:JARID1A | KDM5A | KDM5A_HUMAN | Lysine-specific demethylase 5A (KDM5A(aa 1-1090)-Flag) | Lysine-specific demethylase 5A (KDM5Flag-KDM5A-FL) | RBBP2 | RBP2
Type:Protein
Mol. Mass.:124246.30
Organism:Homo sapiens (Human)
Description:Truncation 1-1090aa
Residue:1090
Sequence:
MAGVGPGGYAAEFVPPPECPVFEPSWEEFTDPLSFIGRIRPLAEKTGICKIRPPKDWQPP
FACEVKSFRFTPRVQRLNELEAMTRVRLDFLDQLAKFWELQGSTLKIPVVERKILDLYAL
SKIVASKGGFEMVTKEKKWSKVGSRLGYLPGKGTGSLLKSHYERILYPYELFQSGVSLMG
VQMPNLDLKEKVEPEVLSTDTQTSPEPGTRMNILPKRTRRVKTQSESGDVSRNTELKKLQ
IFGAGPKVVGLAMGTKDKEDEVTRRRKVTNRSDAFNMQMRQRKGTLSVNFVDLYVCMFCG
RGNNEDKLLLCDGCDDSYHTFCLIPPLPDVPKGDWRCPKCVAEECSKPREAFGFEQAVRE
YTLQSFGEMADNFKSDYFNMPVHMVPTELVEKEFWRLVSSIEEDVIVEYGADISSKDFGS
GFPVKDGRRKILPEEEEYALSGWNLNNMPVLEQSVLAHINVDISGMKVPWLYVGMCFSSF
CWHIEDHWSYSINYLHWGEPKTWYGVPSHAAEQLEEVMRELAPELFESQPDLLHQLVTIM
NPNVLMEHGVPVYRTNQCAGEFVVTFPRAYHSGFNQGYNFAEAVNFCTADWLPIGRQCVN
HYRRLRRHCVFSHEELIFKMAADPECLDVGLAAMVCKELTLMTEEETRLRESVVQMGVLM
SEEEVFELVPDDERQCSACRTTCFLSALTCSCNPERLVCLYHPTDLCPCPMQKKCLRYRY
PLEDLPSLLYGVKVRAQSYDTWVSRVTEALSANFNHKKDLIELRVMLEDAEDRKYPENDL
FRKLRDAVKEAETCASVAQLLLSKKQKHRQSPDSGRTRTKLTVEELKAFVQQLFSLPCVI
SQARQVKNLLDDVEEFHERAQEAMMDETPDSSKLQMLIDMGSSLYVELPELPRLKQELQQ
ARWLDEVRLTLSDPQQVTLDVMKKLIDSGVGLAPHHAVEKAMAELQELLTVSERWEEKAK
VCLQARPRHSVASLESIVNEAKNIPAFLPNVLSLKEALQKAREWTAKVEAIQSGSNYAYL
EQLESLSAKGRPIPVRLEALPQVESQVAAARAWRERTGRTFLKKNSSHTLLQVLSPRTDI
GVYGSGKNRR
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM191600
n/a
NameBDBM191600
Synonyms:2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl)isonicotinic acid (N19) | US10173996, Example 89 | US9604961, Example 89 | US9714230, 89 | US9908865, Example 89
TypeSmall organic molecule
Emp. Form.C17H14ClN3O3
Mol. Mass.343.764
SMILESCc1cc(Cl)ccc1COc1ccnn1-c1cc(ccn1)C(O)=O
Structure
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