| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome b |
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| Ligand | BDBM192008 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Cytochrome b Enzyme Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 7±n/a nM |
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| Comments | extracted |
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| Citation |  Vincent, BM; Langlois, JB; Srinivas, R; Lancaster, AK; Scherz-Shouval, R; Whitesell, L; Tidor, B; Buchwald, SL; Lindquist, S A Fungal-Selective Cytochrome bc1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance. Cell Chem Biol23:978-991 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome b |
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| Name: | Cytochrome b |
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| Synonyms: | COB | CYB_HUMAN | CYTB | MT-CYB | MTCYB |
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| Type: | Protein |
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| Mol. Mass.: | 42724.13 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 380 |
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| Sequence: | MTPMRKTNPLMKLINHSFIDLPTPSNISAWWNFGSLLGACLILQITTGLFLAMHYSPDAS
TAFSSIAHITRDVNYGWIIRYLHANGASMFFICLFLHIGRGLYYGSFLYSETWNIGIILL
LATMATAFMGYVLPWGQMSFWGATVITNLLSAIPYIGTDLVQWIWGGYSVDSPTLTRFFT
FHFILPFIIAALATLHLLFLHETGSNNPLGITSHSDKITFHPYYTIKDALGLLLFLLSLM
TLTLFSPDLLGDPDNYTLANPLNTPPHIKPEWYFLFAYTILRSVPNKLGGVLALLLSILI
LAMIPILHMSKQQSMMFRPLSQSLYWLLAADLLILTWIGGQPVSYPFTIIGQVASVLYFT
TILILMPTISLIENKMLKWA
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| BDBM192008 |
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| n/a |
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| Name | BDBM192008 |
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| Synonyms: | Antimycin A | [(2R,3S,6S,7R)-3-[(3-formamido-2-hydroxybenzoyl)amino]-8-hexyl-2,6-dimethyl-4,9-dioxo-1,5-dioxonan-7-yl] 3-methylbutanoate |
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| Type | Small organic molecule |
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| Emp. Form. | C28H40N2O9 |
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| Mol. Mass. | 548.6252 |
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| SMILES | CCCCCCC1[C@@H](OC(=O)CC(C)C)[C@H](C)OC(=O)[C@@H](NC(=O)c2cccc(NC=O)c2O)[C@@H](C)OC1=O |
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| Structure | 
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