| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Cholesteryl ester transfer protein |
|---|
| Ligand | BDBM192306 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | CETP Inhibition Assay |
|---|
| Temperature | 310.15±n/a K |
|---|
| IC50 | 6±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Nakamura, T; Namiki, H; Terasaka, N; Shima, A; Hagihara, M; Iwase, N; Takata, K; Kikuchi, O; Tsuboike, K; Setoguchi, H; Yoneda, K; Sunamoto, H; Ito, K Substituted pyridine compound US Patent US9187450 Publication Date 11/17/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Cholesteryl ester transfer protein |
|---|
| Name: | Cholesteryl ester transfer protein |
|---|
| Synonyms: | CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 54751.53 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11597 |
|---|
| Residue: | 493 |
|---|
| Sequence: | MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDI
TGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTT
AWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWI
KQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVI
TASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL
MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSS
VMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSE
SVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGF
PEHLLVDFLQSLS
|
|
|
|---|
| BDBM192306 |
|---|
| n/a |
|---|
| Name | BDBM192306 |
|---|
| Synonyms: | US9187450, 52 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C39H49F6N5O3S |
|---|
| Mol. Mass. | 781.893 |
|---|
| SMILES | CC(C)S(=O)(=O)N(C)Cc1cnc(nc1)N1CCC(CC1)c1nc2CC(C)(C)C[C@H](O)c2c(C2CCC(F)(F)CC2)c1[C@@H](F)c1ccc(cc1)C(F)(F)F |r| |
|---|
| Structure | 
|
|---|
Search and Browse
