| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 1 [8-360] |
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| Ligand | BDBM192335 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Assay |
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| pH | 7.3±n/a |
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| IC50 | 1.2±n/a nM |
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| Comments | extracted |
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| Citation |  Blake, JF; Chen, H; Chicarelli, MJ; Demeese, J; Garrey, RF; Gaudino, J; Gazzard, L; Kaus, RJ; Kintz, S; Mohr, PJ; Moreno, DA; Schwarz, J; Siedem, CS; Wallace, EM Substituted quinazolines as serine/threonine kinase inhibitors US Patent US9187462 Publication Date 11/17/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 1 [8-360] |
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| Name: | Mitogen-activated protein kinase 1 [8-360] |
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| Synonyms: | ERK2 | Human ERK-2 | MAPK1 | MK01_HUMAN | Mitogen Activated Kinase 1 | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (aa 8-360) | PRKM1 | PRKM2 |
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| Type: | n/a |
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| Mol. Mass.: | 40835.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P28482 aa 8-360 |
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| Residue: | 353 |
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| Sequence: | GAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQR
TLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHIC
YFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEY
VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSP
SQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQA
LAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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| BDBM192335 |
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| n/a |
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| Name | BDBM192335 |
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| Synonyms: | US9187462, I-15 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H22ClFN6O2 |
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| Mol. Mass. | 468.911 |
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| SMILES | CC(CO)Nc1ncc2ccc(cc2n1)C(=O)N[C@H](c1cnn(C)c1)c1ccc(Cl)c(F)c1 |r| |
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| Structure | 
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