Reaction Details | |||
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Target | Mitogen-activated protein kinase 1 [8-360] | ||
Ligand | BDBM192403 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Enzymatic Assay | ||
pH | 7.3±n/a | ||
IC50 | 1.2±n/a nM | ||
Comments | extracted | ||
Citation | Blake, JF; Chen, H; Chicarelli, MJ; Demeese, J; Garrey, RF; Gaudino, J; Gazzard, L; Kaus, RJ; Kintz, S; Mohr, PJ; Moreno, DA; Schwarz, J; Siedem, CS; Wallace, EM Substituted quinazolines as serine/threonine kinase inhibitors US Patent US9187462 Publication Date 11/17/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Mitogen-activated protein kinase 1 [8-360] | |||
Name: | Mitogen-activated protein kinase 1 [8-360] | ||
Synonyms: | ERK2 | Human ERK-2 | MAPK1 | MK01_HUMAN | Mitogen Activated Kinase 1 | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (aa 8-360) | PRKM1 | PRKM2 | ||
Type: | n/a | ||
Mol. Mass.: | 40835.09 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P28482 aa 8-360 | ||
Residue: | 353 | ||
Sequence: |
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BDBM192403 | |||
n/a | |||
Name | BDBM192403 | ||
Synonyms: | US9187462, II-13 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H28F2N6O3 | ||
Mol. Mass. | 522.5464 | ||
SMILES | COc1ccc(cc1F)[C@H](NC(=O)c1cc(F)c2cnc(N[C@H]3CC[C@H](O)CC3)nc2c1)c1cnn(C)c1 |r,wU:22.22,9.10,wD:25.26,(9.38,1.49,;8.05,2.26,;6.72,1.49,;5.33,2.24,;4,1.47,;4,-.07,;5.33,-.84,;6.67,-.07,;8,-.84,;2.67,-.84,;1.33,-.07,;1.33,1.47,;2.67,2.24,;,2.24,;,3.78,;-1.33,4.55,;-1.33,6.09,;-2.67,3.78,;-4,4.55,;-5.33,3.78,;-5.33,2.24,;-6.67,1.47,;-6.67,-.07,;-5.33,-.84,;-5.33,-2.38,;-6.67,-3.15,;-6.67,-4.69,;-8,-2.38,;-8,-.84,;-4,1.47,;-2.67,2.24,;-1.33,1.47,;2.67,-2.38,;3.91,-3.29,;3.44,-4.75,;1.87,-4.79,;.97,-6.03,;1.42,-3.29,)| | ||
Structure |