Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetSerine/threonine-protein kinase A-Raf
LigandBDBM192503
Substrate/Competitorn/a
Meas. Tech.KiNativ assay
IC50 31±n/a nM
Citation Flynn, DLKaufman, MDVogeti, LWise, SLu, WSmith, BCaldwell, TMPatt, WCHenry, JRHipskind, PAPeng, S Raf inhibitor compounds US Patent US9187474 Publication Date 11/17/2015
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase A-Raf
Name:Serine/threonine-protein kinase A-Raf
Synonyms:ARAF | ARAF1 | ARAF_HUMAN | PKS | PKS2 | Proto-oncogene A-Raf | Proto-oncogene A-Raf-1 | Proto-oncogene Pks | RAF serine/threonine protein kinase
Type:Enzyme
Mol. Mass.:67610.81
Organism:Homo sapiens (Human)
Description:P10398
Residue:606
Sequence:
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELL
TPQGPSPRTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFS
TDAAGSRGGSDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLS
AARLVP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM192503
n/a
NameBDBM192503
Synonyms:US9187474, 18
TypeSmall organic molecule
Emp. Form.C23H28FN5O
Mol. Mass.409.4997
SMILESCNc1cc2nc(C)c(cc2cn1)-c1cc(NC(=O)NCCC(C)(C)C)ccc1F
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: