Reaction Details |
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Target | Geranylgeranyl pyrophosphate synthase |
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Ligand | BDBM12578 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Radioactive Assay |
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IC50 | >1.00e+5±n/a nM |
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Citation | Teng, KH; Hsu, ET; Chang, YH; Lin, SW; Liang, PH Fluorescent Farnesyl Diphosphate Analogue: A Probe To Validate trans-Prenyltransferase Inhibitors. Biochemistry55:4366-74 (2016) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Geranylgeranyl pyrophosphate synthase |
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Name: | Geranylgeranyl pyrophosphate synthase |
Synonyms: | Dimethylallyltranstransferase | Farnesyltranstransferase | GGPP synthetase | GGPPS_HUMAN | GGPPSase | GGPS1 | Geranylgeranyl Diphosphate Synthase (GGPPS) | Geranylgeranyl diphosphate synthase | Geranylgeranyl pyrophosphate synthetase | Geranyltranstransferase |
Type: | Homooctamer; transferase |
Mol. Mass.: | 34867.94 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant human GGPPS was cloned and expressed in E. coli. |
Residue: | 300 |
Sequence: | MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNAS
LLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLL
ELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTL
GLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTEN
IDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE
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BDBM12578 |
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n/a |
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Name | BDBM12578 |
Synonyms: | 2-(imidazol-1-yl)-1-hydroxyethylidene-1,1-bisphosphonic acid | Bisphosphonate 3 | CGP-42446 | CHEMBL924 | JMC515594 Compound 55 | Reclast | US11279719, Example Zolendronic acid (ZOL) | ZOL | Zoledronate | Zometa | [1-hydroxy-2-(1H-imidazol-1-yl)-1-phosphonoethyl]phosphonic acid | zoledronic acid |
Type | Small organic molecule |
Emp. Form. | C5H10N2O7P2 |
Mol. Mass. | 272.0896 |
SMILES | OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O |
Structure |
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