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TargetPhosphodiesterase 10A (PDE10A2)
LigandBDBM194134
Substrate/Competitorn/a
Meas. Tech.Fluorescence Polarization Assay
Ki 0.14±n/a nM
Citation Cox CDDudkin VYKim JJKuduk SDMcVean CAReger TSheen JTSteele T Triazolyl PDE10 inhibitors US Patent  US9200001 Publication Date 12/1/2015
More Info.:Get all data from this article,  Assay Method
 
Phosphodiesterase 10A (PDE10A2)
Name:Phosphodiesterase 10A (PDE10A2)
Synonyms:Phosphodiesterase 10A | Phosphodiesterase 10A2 | Phosphodiesterase 10A2 (PDE10A)
Type:Enzyme
Mol. Mass.:89387.03
Organism:Homo sapiens (Human)
Description:Q9Y233-2
Residue:789
Sequence:
MEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLHPQVLDEFVSESVSAETVEKWLKRK
NNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIKIATKAD
GFALYFLGECNNSLCIFTPPGIKEGKPRLIPAGPITQGTTVSAYVAKSRKTLLVEDILGD
ERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLSHQEVATANLAWA
SVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALF
QVDHKNKELYSDLFDIGEEKEGKPVFKKTKEIRFSIEKGIAGQVARTGEVLNIPDAYADP
RFNREVDLYTGYTTRNILCMPIVSRGSVIGVVQMVNKISGSAFSKTDENNFKMFAVFCAL
ALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIG
PFENMWPGIFVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAHCMYAI
LQNNHTLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQTV
SILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQLEEMYQTGSLNLNNQS
HRDRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGDEMKKLGIQPIPMMDRDKKD
EVPQGQLGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQWEKVIRGEETATWISSPSV
AQKAAASED
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  Blast E-value cutoff:
BDBM194134
n/a
NameBDBM194134
Synonyms:US9200001, 50
TypeSmall organic molecule
Emp. Form.C17H20N6
Mol. Mass.308.3809
SMILESCc1nc(C)n(n1)-c1cc(CCc2ccc(C)cn2)nc(C)n1
Structure
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