Reaction Details |
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Target | Hypoxanthine-guanine phosphoribosyltransferase |
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Ligand | BDBM194500 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Spectrophotometric Assay |
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pH | 7.4±n/a |
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Ki | 100±20 nM |
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Comments | extracted |
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Citation | De Jersey, J; Guddat, LW; Hockova, D; Keough, DT 6-oxopurine phosphoribosyltransferase inhibitors US Patent US9200020 Publication Date 12/1/2015 |
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More Info.: | Get all data from this article, Assay Method |
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Hypoxanthine-guanine phosphoribosyltransferase |
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Name: | Hypoxanthine-guanine phosphoribosyltransferase |
Synonyms: | HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT) |
Type: | Protein |
Mol. Mass.: | 24579.61 |
Organism: | Homo sapiens (Human) |
Description: | P00492 |
Residue: | 218 |
Sequence: | MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
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BDBM194500 |
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n/a |
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Name | BDBM194500 |
Synonyms: | US9200020, Table 3 compound 9 |
Type | Small organic molecule |
Emp. Form. | C13H22N6O6P |
Mol. Mass. | 389.3241 |
SMILES | Nc1nc2n(CCN(CCCC(O)=O)CCP(O)(O)=O)c[nH]c2c(=O)[nH]1 |
Structure |
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