| Reaction Details |
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 | Report a problem with these data |
| Target | ADAM metallopeptidase with thrombospondin type 1 motif 4 |
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| Ligand | BDBM194638 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | AlphaScreen Assay |
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| pH | 7.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 1±n/a nM |
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| Comments | extracted |
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| Citation |  Durham, TB; Marimuthu, J; Wiley, MR Aggrecanase inhibitors US Patent US9206139 Publication Date 12/8/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| ADAM metallopeptidase with thrombospondin type 1 motif 4 |
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| Name: | ADAM metallopeptidase with thrombospondin type 1 motif 4 |
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| Synonyms: | Metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) |
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| Type: | Enzyme |
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| Mol. Mass.: | 106624.01 |
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| Organism: | Canis lupus familiaris (Dog) |
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| Description: | A0A8I3Q3A2 |
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| Residue: | 992 |
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| Sequence: | MLKSAGARREAGKDSRGDPQTHRHGRERRRETETKAQRTKPETGQAQRKARQCEGHREAR
GAAGGTGRGRQRPGRGGGARGVWRSQATGRLSAAEGPGSLHLRRRSPAPLQTLPLTLAQV
RAPRLRRGVFQSRGGENLVRSRPPSLPGRGASAMAPTDRRPRRGLAGCWLWGAGPRLPLP
ALPTARPAARLLLPLLLSALLPSGRPAGPLPREEEIVFPERLNGSVPPGLGAPARLLCRL
PAFGETLLLELEQDPGVRVEGLTVQYLGRAPELLGGAEPGTYLTGSINGDPESVASLHWD
GGALLGVLQYRGTELHIQPLEGGSLNSAGGPGAHILRRKSPASGQGPMCNVKAPPGNPSP
SPRRAKRFASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAKAFKHPSIRNPVSLV
VTRLVILGPGEEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVS
TCDTLGMADVGTVCDPARSCAVVEDDGLQSAFTAAHELGHVFNMLHDNSKSCADLNGPGS
TSRHVMAPVMAHVDPEEPWSPCSAHFITEFLDNGYGHCLLDKPEAPLHLPVTFPGKDYDA
DRQCQLTFGPDSRHCPQLPPPCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGR
CLHVDQLQDFNIPQAGGWGPWGPWGDCSRSCGGGVQFSSRDCTRPVPRNGGKYCEGRRTR
FRSCNTQDCPTGSALTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPRDQCKLTCQA
RALGYYYVLEPRVVDGTPCSPDSSSVCVQGRCIHAGCDRVIGSKKKFDKCMVCGGDGSSC
SKQSGSFRKFRYGYNNVVTIPAGATHILVRQQGTPGLRSLYLALKLPDGSYALNGEYTLM
PSPTDVVLPGAVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQNARLRYSFFVPRP
APATARPTPQDWLQRKAQILEILRRRPWAGRK
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| BDBM194638 |
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| n/a |
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| Name | BDBM194638 |
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| Synonyms: | US9206139, 1 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H20F3N3O3 |
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| Mol. Mass. | 383.3649 |
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| SMILES | C[C@H](Cc1ccc(cc1)C(F)(F)F)C(=O)NC[C@]1(NC(=O)NC1=O)C1CC1 |r| |
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| Structure | 
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