| Reaction Details |
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 | Report a problem with these data |
| Target | ADAM metallopeptidase with thrombospondin type 1 motif, 5 |
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| Ligand | BDBM194644 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Shift AlphaScreen Assay |
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| IC50 | 18±n/a nM |
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| Citation |  Durham, TB; Marimuthu, J; Wiley, MR Aggrecanase inhibitors US Patent US9206139 Publication Date 12/8/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| ADAM metallopeptidase with thrombospondin type 1 motif, 5 |
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| Name: | ADAM metallopeptidase with thrombospondin type 1 motif, 5 |
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| Synonyms: | Metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) |
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| Type: | Enzyme |
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| Mol. Mass.: | 101805.04 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | G3V673 |
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| Residue: | 927 |
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| Sequence: | MRLEWASLLLLLLLLCASCLALAADNPAAAPAQDKTRQPRAAAAAAQPDQRQWEETQERG
HPQPLARQRRSSGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDDTVGAAGGIVTAGG
LSASSGHRGHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGSWAESERV
YGDGSSRILHVYTREGFSFEALPPRTSCETPASPSGAQESPSVHSSSRRRTELAPQLLDH
SAFSPAGNAGPQTWWRRRRRSISRARQVELLLVADSSMAKMYGRGLQHYLLTLASIANRL
YSHASIENHIRLAVVKVVVLTDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAI
LFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDS
KFCEENFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDVPRKQILGP
EELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCG
KGRICLQGKCVDKTKKKYYSTSSHGNWGSWGPWGQCSRSCGGGVQFAYRHCNNPAPRNSG
RYCTGKRAIYRSCSVIPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPAD
VCKLTCRAKGTGYYVVFSPKVTDGTECRPYSNSVCVRGRCVRTGCDGIIGSKLQYDKCGV
CGGDNSSCTKIIGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKTGE
YLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKAL
DVRYSFFVPKKTTQKVNSVISHSSNKVGLHSPQLQWVTGPWLACSRTCDTGWHTRTVQCQ
DGNRKLAKGCILSQRPSAFKQCLLKKC
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| BDBM194644 |
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| n/a |
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| Name | BDBM194644 |
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| Synonyms: | US9206139, 3 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22F3N3O3 |
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| Mol. Mass. | 409.4022 |
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| SMILES | FC(F)(F)c1ccc(C[C@@H](C2CC2)C(=O)NC[C@]2(NC(=O)NC2=O)C2CC2)cc1 |r| |
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| Structure | 
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