Reaction Details |
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Target | ADAM metallopeptidase with thrombospondin type 1 motif, 5 |
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Ligand | BDBM194645 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Shift AlphaScreen Assay |
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IC50 | 146±n/a nM |
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Citation | Durham, TB; Marimuthu, J; Wiley, MR Aggrecanase inhibitors US Patent US9206139 Publication Date 12/8/2015 |
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More Info.: | Get all data from this article, Assay Method |
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ADAM metallopeptidase with thrombospondin type 1 motif, 5 |
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Name: | ADAM metallopeptidase with thrombospondin type 1 motif, 5 |
Synonyms: | Metalloproteinase with thrombospondin motifs 5 (ADAMTS-5) |
Type: | Enzyme |
Mol. Mass.: | 101805.04 |
Organism: | Rattus norvegicus (Rat) |
Description: | G3V673 |
Residue: | 927 |
Sequence: | MRLEWASLLLLLLLLCASCLALAADNPAAAPAQDKTRQPRAAAAAAQPDQRQWEETQERG
HPQPLARQRRSSGLVQNIDQLYSGGGKVGYLVYAGGRRFLLDLERDDTVGAAGGIVTAGG
LSASSGHRGHCFYRGTVDGSPRSLAVFDLCGGLDGFFAVKHARYTLKPLLRGSWAESERV
YGDGSSRILHVYTREGFSFEALPPRTSCETPASPSGAQESPSVHSSSRRRTELAPQLLDH
SAFSPAGNAGPQTWWRRRRRSISRARQVELLLVADSSMAKMYGRGLQHYLLTLASIANRL
YSHASIENHIRLAVVKVVVLTDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAI
LFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDS
KFCEENFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDVPRKQILGP
EELPGQTYDATQQCNLTFGPEYSVCPGMDVCARLWCAVVRQGQMVCLTKKLPAVEGTPCG
KGRICLQGKCVDKTKKKYYSTSSHGNWGSWGPWGQCSRSCGGGVQFAYRHCNNPAPRNSG
RYCTGKRAIYRSCSVIPCPPNGKSFRHEQCEAKNGYQSDAKGVKTFVEWVPKYAGVLPAD
VCKLTCRAKGTGYYVVFSPKVTDGTECRPYSNSVCVRGRCVRTGCDGIIGSKLQYDKCGV
CGGDNSSCTKIIGTFNKKSKGYTDVVRIPEGATHIKVRQFKAKDQTRFTAYLALKKKTGE
YLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMGYSATKEILIVQILATDPTKAL
DVRYSFFVPKKTTQKVNSVISHSSNKVGLHSPQLQWVTGPWLACSRTCDTGWHTRTVQCQ
DGNRKLAKGCILSQRPSAFKQCLLKKC
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BDBM194645 |
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n/a |
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Name | BDBM194645 |
Synonyms: | US9206139, 4 |
Type | Small organic molecule |
Emp. Form. | C20H24F3N3O3 |
Mol. Mass. | 411.4181 |
SMILES | CC(C)[C@H](Cc1ccc(cc1)C(F)(F)F)C(=O)NC[C@]1(NC(=O)NC1=O)C1CC1 |r| |
Structure |
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