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TargetBeta-secretase 1 [1-458]
LigandBDBM195421
Substrate/Competitorn/a
Meas. Tech.BACE Enzyme Assay (Ex.434)
pH4.5±n/a
Temperature298.15±n/a K
IC50 4±n/a nM
Commentsextracted
Citation Cacatian, SClaremon, DADillard, LWFuchs, KHeine, NJia, LLeftheris, KMcKeever, BMorales-Ramos, ASingh, SBVenkatraman, SWu, GWu, ZXu, ZYuan, JZheng, Y Inhibitors of beta-secretase US Patent US9212153 Publication Date 12/15/2015
More Info.:Get all data from this article,  Assay Method
 
Beta-secretase 1 [1-458]
Name:Beta-secretase 1 [1-458]
Synonyms:BACE | BACE1 | BACE1_HUMAN | Beta-secretase 1 (aa 1-458) | KIAA1149
Type:n/a
Mol. Mass.:50753.53
Organism:Homo sapiens (Human)
Description:Truncation 1-458 aa with His-tag at C-terminus
Residue:458
Sequence:
MAQALPWLLLWMGAGVLPAHGTQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTLDMEDCGYNIPQTDESTLMTI
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  Blast E-value cutoff:
BDBM195421
n/a
NameBDBM195421
Synonyms:US9212153, 4
TypeSmall organic molecule
Emp. Form.C26H27N3O2
Mol. Mass.413.5115
SMILESn/a
Structure
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