Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetLysophospholipase-like 1 (LYPLAL1)
LigandBDBM195578
Substrate/Competitorn/a
Meas. Tech.Gel-based ABPP (LYPLAL1)
pH7.5±n/a
IC50 11± 0 nM
Commentsextracted
Citation Ahn KBoehm MBrown MFCalloway JChe YChen JFennell KFGeoghegan KFGilbert AMGutierrez JAKalgutkar ASLanba ALimberakis CMagee TVO'Doherty IOliver RPabst BPandit JParris KPfefferkorn JARolph TPPatel RSchuff BShanmugasundaram VStarr JTVarghese AHVera NBVernochet CYan J Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism. ACS Chem Biol 11:2529-40 (2016) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Lysophospholipase-like 1 (LYPLAL1)
Name:Lysophospholipase-like 1 (LYPLAL1)
Synonyms:n/a
Type:Protein
Mol. Mass.:26322.18
Organism:Homo sapiens (Human)
Description:n/a
Residue:237
Sequence:
MAAASGSVLQRCIVSPAGRHSASLIFLHGSGDSGQGLRMWIKQVLNQDLTFQHIKIIYPT
APPRSYTPMKGGISNVWFDRFKITNDCPEHLESIDVMCQVLTDLIDEEVKSGIKKNRILI
GGFSMGGCMAIHLAYRNHQDVAGVFALSSFLNKASAVYQALQKSNGVLPELFQCHGTADE
LVLHSWAEETNSMLKSLGVTTKFHSFPNVYHELSKTELDILKLWILTKLPGEMEKQK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM195578
n/a
NameBDBM195578
Synonyms:(2R, 4R)-1-(3-(4-(2-morpholinopyrimidin-5-yl)phenyl)-1H-1,2,4-triazole-1-carbonyl)-2-phenylpiperidine-4-carboxylic acid (9)
TypeSmall organic molecule
Emp. Form.C29H29N7O4
Mol. Mass.539.5851
SMILESOC(=O)[C@@H]1CCN([C@H](C1)c1ccccc1)C(=O)n1cnc(n1)-c1ccc(cc1)-c1cnc(nc1)N1CCOCC1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: